Results 201 to 210 of about 104,548 (291)

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Late blight pathogen targets host Rab‐G3 GTPases with an atypical GTPase‐activating protein

Journal of Integrative Plant Biology, EarlyView.
The Phytophthora infestans RXLR effector Pi17063 functions as an atypical GTPase‐activating protein of host positive immune regulators, specifically the small GTPase NbRab‐G3. Pi17063 promotes the relocalization of NbRab‐G3 proteins to the cytoplasm, where they are inactive, disrupting the balance of the NbRab‐G3 switch and thus leading to enhanced ...
Song Liu, Liwen Ding, Xiong Liu, Xiaoxi Xing, Jinyang Li, Tiantian Yan, Yuli Huang, Yuan Liu, Yisa Wang, Xia Zhang, Zeming Liu, Xiyu Cao, Yuling Meng, Weixing Shan   +13 more
wiley   +1 more source

High voltage activated Ca2+ channel [PDF]

, 1993
A Cavalié, A Hui, A Mikami, A Röhrkasten, A Welling, A Welling, AE Lacerda, AM Brown, C Kleuss, C Mundina-Weilenmann, D Singer, E Bosse, E Bosse, E Perez-Reyes, E Perez-Reyes, E Perez-Reyes, E Rios, EI Rotman, F Hofmann, G Varadi, H Nakayama, HL Kim, HR Guy, HS Kim, IM Mintz, J Garcia, J Striessnig, J Striessnig, K Itagaki, K Nunoki, KS Jongh De, KS Jongh De, KS Jongh De, L Hymel, M Bertolino, M Biel, M Biel, M Kameyama, M Pragnell, ME Williams, ME Williams, P Lory, P Ruth, R Hullin, R Staudinger, RI Norman, RJ Diebold, RJ Miller, RS Kass, S Hamilton, S Regulla, S Seino, SB Ellis, SD Jay, SD Jay, SJ Dubel, T Schneider, T Tanabe, T Tanabe, T Tanabe, T Tanabe, TP Snutch, TP Snutch, TVB Starr, U Klöckner, V Flockerzi, W Trautwein, WJ Koch, X Wei, Y Lai, Y Mori   +70 more
core   +1 more source

Glomerular ultrastructural change and vascular endothelial growth factor‐A expression in diabetic cats

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the glomerular ultrastructural changes associated with diabetic nephropathy and quantify glomerular vascular endothelial growth factor‐A expression in cats with diabetes mellitus compared to controls. Materials and Methods Transmission electron microscopy was performed to evaluate glomerular ultrastructural changes, including ...
H. Reyes‐Hughes, E. Bird, C. Neal, R. Noiva, R. R. Foster, S. Satchell, N. Finch   +6 more
wiley   +1 more source

Regulation of Protein Synthesis at the Translational Level: Novel Findings in Cardiovascular Biology. [PDF]

Biomolecules
Tsoy S, Liu J.
europepmc   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, EarlyView.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source

RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer's Disease. [PDF]

Curr Issues Mol Biol
Medd MM, Yon JE, Dong H.
europepmc   +1 more source

Modulation of lignin and anthocyanin homeostasis by GTP cyclohydrolase1 in maize

Plant Biotechnology Journal, EarlyView.
Summary Maize is a key biomass resource with wide agricultural applications. Anthocyanins, potent antioxidants, offer health benefits like reducing oxidative stress. The biosynthesis of anthocyanins competes with that of lignin for shared metabolic precursors, which can lead to trade‐offs in plant growth and feed quality.
Mingyue Zhang, Xiaohan Li, Xiao Wang, Shuzhen Jiang, Junli Zhang, Mingfei Sun, Zixian Zhou, Jinxiao Zhang, Mengyao Li, Yanxiao Lv, Enlong Qi, Ziang Tian, Hongjie Zhu, Xuebin Zhang, Xiangyu Zhao, Changcheng Xu, Thomas Lübberstedt, Xiansheng Zhang, Xuerong Yang, Chao Zhou, Hongjun Liu   +20 more
wiley   +1 more source

Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. [PDF]

PLoS Pathog
Malik HS, Bliska JB.
europepmc   +1 more source

RabE1a‐ and SEC10b‐mediated exocytosis and AP2β‐mediated endocytosis are involved in the intracellular transport of tobamoviruses

Plant Biotechnology Journal, EarlyView.
Summary To establish systemic infection, plant viruses must replicate, and conduct intra‐ and intercellular movement and long‐distance movement, all of which require the participation of host factors. Tobamoviruses move in the form of movement protein (MP)–viral RNA complex and utilize endocytosis for intracellular movement.
Hua‐Yu Ma, Yu Kong, Chao Geng, Yan‐Ping Tian, Jun Jiang, Zhi‐Yong Yan, Xiang‐Dong Li   +6 more
wiley   +1 more source