Results 221 to 230 of about 104,548 (291)

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Neurotransmitter release was characterized at post‐hearing rat calyx of Held synapses, before and after pharmacologically augmenting synaptic strength, by recording unitary EPSCs, or capacitance changes in response to presynaptic step depolarizations.
Kun‐Han Lin, Mrinalini Ranjan, Noa Lipstein, Nils Brose, Erwin Neher, Holger Taschenberger   +5 more
wiley   +1 more source

Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide. [PDF]

Med Gas Res
Farahani A, Farahani A, Kashfi K, Ghasemi A.   +3 more
europepmc   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D'Este, Michael Fauth, Rubén Fernández‐Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón‐Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli   +35 more
wiley   +1 more source

A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants. [PDF]

Comput Struct Biotechnol J
Cabral Oliveira C, Bassi Simoni E, Abrahão Bueno Morais M, Pacheco Batista Fontes E, Braga Dos Reis PA, Urano D, Jones AM.   +6 more
europepmc   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

A PDZ-kinase allosteric relay mediates Par complex regulator exchange. [PDF]

J Biol Chem
Vargas E, Penkert RR, Prehoda KE.
europepmc   +1 more source

Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development

The Journal of Physiology, EarlyView.
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang, Adam Fekete, Jason Arsenault, Ameet S. Sengar, Jamila Aitoubah, Giovanbattista Grande, Angela Li, Eric W. Salter, Alex Wang, Melanie D. Mark, Stefan Herlitze, Sean E. Egan, Michael W. Salter, Lu‐Yang Wang   +13 more
wiley   +1 more source

The role of RAC1 in resistance to targeted therapies in cancer. [PDF]

Small GTPases
Uribe-Alvarez C, Chernoff J.
europepmc   +1 more source

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source