Results 221 to 230 of about 80,664 (305)

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, Volume 35, Issue 6, November 2025.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution. [PDF]

Elife
Merino-Salomón A, Scheneider J, Babl L, Krohn JH, Sobrinos-Sanguino M, Schaefer T, Luque-Ortega JR, Alfonso C, Jiménez M, Jasnin M, Schwille P, Rivas G.   +11 more
europepmc   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Integrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy. [PDF]

Front Immunol
Peng L, Li H, Yan W, Liu Y, Zhu H, Hong Y.   +5 more
europepmc   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, Volume 108, Issue 5, Page 589-593, November 2025.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

The Role of Translation-Associated Proteins in p53 Modulation: Mechanisms and Implications. [PDF]

Int J Mol Sci
Kałużyńska D.
europepmc   +1 more source

Effect of Depletion of Developmentally Regulated GTP Binding Protein on Osteoblastic Differentiation and Bone Microarchitecture

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Previous studies have demonstrated that overexpression of DRG2 enhances the osteoclastic activity. However, its impact on osteoblastic differentiation remains unexplored. This study investigates the relationship between DRG2 and osteoblastic activity through in vitro and in vivo studies.
Yuan‐Zhe Jin, Minjoon Cho, Jae Hyup Lee   +2 more
wiley   +1 more source

YAP controls cell migration and invasion through a Rho GTPase switch. [PDF]

Sci Signal
Shah SR, Ren C, Tippens ND, Park J, Mohyeldin A, Wang S, Vela G, Martinez-Gutierrez JC, Margolis SS, Schmidt S, Quiñones-Hinojosa A, Levchenko A.   +11 more
europepmc   +1 more source

Lithium in plants

New Phytologist, Volume 248, Issue 4, Page 1639-1654, November 2025.
Summary The physiological significance of lithium (Li+) remains largely unexplored in plants despite its consistent presence in at least trace concentrations in plant tissues. While Li+ has traditionally been associated with salinity‐like stress symptoms and presumed to utilise sodium (Na+) transport pathways, accumulating evidence points to multiple ...
Sebastian Garcia‐Daga, Sina Fischer, Matthew Gilliham   +2 more
wiley   +1 more source