Results 221 to 230 of about 149,249 (343)

Methods for Controlling Small GTPase Activity. [PDF]

Chembiochem
Faulkner B, He Y, Sitrin D, Stains CI.
europepmc   +1 more source

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

KRAS: the Achilles' heel of pancreas cancer biology. [PDF]

J Clin Invest
Drizyte-Miller K, Talabi T, Somasundaram A, Cox AD, Der CJ.   +4 more
europepmc   +1 more source

Gαs‐specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins

The FEBS Journal, EarlyView.
Heterotrimeric (αβγ) G proteins are usually inactivated by regulators of G protein signaling (RGS) proteins, but Gαs is an exception. Comparative structural analysis identified unique Gαs structural elements that may interfere with RGS binding. Mutagenesis and biochemical assays showed that three residues in the Gαs GTPase domain are both necessary and
Sabreen Higazy‐Mreih, Meirav Avital‐Shacham, Christian LeGouill, Michel Bouvier, Mickey Kosloff   +4 more
wiley   +1 more source

Asgard Arf GTPases can act as membrane-associating molecular switches with the potential to function in organelle biogenesis. [PDF]

Nat Commun
Zhu J, Xie R, Ren Q, Zhou J, Chen C, Xie MX, Zhou Y, Zhang Y, Liu N, Wang J, Zhang Z, Liu X, Yan W, Gong Q, Dong L, Zhu J, Wang F, Xie Z.   +17 more
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling. [PDF]

Protein Sci
Jabbar J, Afroze B, Ling NXY, Oakhill JS, Rouiller I.   +4 more
europepmc   +1 more source

Biochemical characterization of phosphoenolpyruvate carboxykinases from multiple species of brown algae

Journal of Phycology, EarlyView.
Abstract Phosphoenolpyruvate carboxykinase (PEPCK) is involved in the conversion of phosphoenolpyruvate (PEP) to oxaloacetate (OAA). In addition to playing a role in gluconeogenesis in various organisms, PEPCK also functions in the C4 cycle to concentrate CO2 for photosynthesis in some C4 plants.
Jian‐qiang Jin, Yuusuke Yokooji, Toshiyuki Shibata, Haruyuki Atomi   +3 more
wiley   +1 more source