Results 231 to 240 of about 104,548 (291)

Potassium‐Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia

Glia, Volume 73, Issue 7, Page 1520-1534, July 2025.
Main Points Astrocytes depolarize to light ON and OFF like Müller glia. The astrocyte light response is due to potassium influx. Retinal macroglial current‐voltage responses exhibit rectification which changes with repeated stimulation. ABSTRACT Astrocytes throughout the central nervous system mediate a variety of functions to support proper tissue ...
Joseph Matthew Holden, Andrew M. Boal, Lauren Katie Wareham, David John Calkins   +3 more
wiley   +1 more source

Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1‐Assisted FA Anion Transport

Acta Physiologica, Volume 241, Issue 7, July 2025.
ABSTRACT Background Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non‐shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduces the proton gradient in the presence of long‐chain fatty acids (FA).
Sanja Vojvodić, Giorgia Roticiani, Mario Vazdar, Elena E. Pohl   +3 more
wiley   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source

Egy szokatlan szerkezetű kis GTPáz növényi cirkadián órában betöltött szerepének vizsgálata [PDF]

, 2009
Gyula Péter
core  

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Decoding Long‐Distance Communication Under Mineral Stress: Advances in Vascular Signalling and Molecular Tools for Plant Resilience

Plant, Cell &Environment, Volume 48, Issue 7, Page 4781-4802, July 2025.
ABSTRACT Mineral nutrients are essential for plant growth, development and crop yield. Under mineral deficient conditions, plants rely on a sophisticated network of signalling pathways to coordinate their molecular, physiological, and morphological responses.
Chao Xia, Juliana Miranda, David Mendoza‐Cozatl, Byung‐Kook Ham, Jianxin Ma, Cankui Zhang   +5 more
wiley   +1 more source

PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly. [PDF]

Cell Mol Life Sci
Qi Y, Yu CH.
europepmc   +1 more source

Deletion of GhSCY2D Causes Impaired Chloroplast Development and Temperature‐Dependent Leaf Yellowing in Cotton (Gossypium hirsutum L.)

Plant, Cell &Environment, Volume 48, Issue 7, Page 4902-4917, July 2025.
ABSTRACT Leaf colour mutants play an important role in understanding chlorophyll metabolism and photosynthesis. In this study, we characterised a temperature‐sensitive yellow leaf cotton mutant. Genome re‐sequencing and comparison identified a 10.327 Kb deletion on the D12 chromosome (D12:670726‐681053) in the mutant.
Xiaokang Feng, Yanmei Ma, Qian Liang, Yanlong Jin, Xuefeng Wang, Jianhang Wang, Feng Liu, Xinyu Zhang, Dongnan Shao, Jie Sun, Qian‐Hao Zhu, Fei Xue   +11 more
wiley   +1 more source