Results 91 to 100 of about 4,605 (211)

Dopa-responsive dystonia and early-onset Parkinson's disease in a patient with GTP cyclohydrolase I deficiency?

, 2006
We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [123I]-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane
Nielsen, J.E., Hjermind, L.E., Regeur, L., Hertz, J.M., Friberg, L., Sorensen, S.A., Johannsen, L.G., Lucking, C.B., Blau, N., Wevers, R.A.   +9 more
core   +1 more source

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 2002
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji   +6 more
doaj   +1 more source

The Characterization of tRNA Modifying Enzymes S-adenosylmethionine : tRNA Ribosyltransferase-isomerase (QueA) and a novel Type I GTP cyclohydrolase

, 2007
Queuosine is a hypermodified nucleoside located in the wobble position of bacterial and eukaryotic tRNAs coding for Asp, Tyr, His and Asn. The biosynthesis involves the participation of S-adenosyl-methionine:tRNA ribosyltransferase-isomerase (QueA) and a
Bonnett, Shilah Amal
core   +2 more sources

Human GTP cyclohydrolase I: Only one out of three cDNA isoforms gives rise to the active enzyme.

, 1994
GTP cyclohydrolase I catalyses the first and rate-limiting step of tetrahydrobiopterin biosynthesis. Its expression is regulated by interferon-γ or kit ligand in a tissue-specific manner.
Gütlich, M., Rücknagel, K.P., Ziegler, I., Werner, T., Bacher, A., Jäger, E., Rödl, W.   +6 more
core  

Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA

, 1995
A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS
Oka, Muneo, Muneo Oka, Nakanishi, Nobuo, Kasai, Kikuo, Shin-Ichi Shimoda, Shimoda, Shin-Ichi, Nobuo Nakanishi, Kikuo Kasai, Yoshiyuki Hattori, Hattori, Yoshiyuki   +9 more
core   +1 more source

BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia

Jornal de Pediatria (Versão em Português), 2018
Objectives: To show the general prevalence and to characterize tetrahydrobiopterin (BH4) deficiencies with hyperphenylalaninemia, identified by the Neonatal Screening Program of the State of Minas Gerais.
Cezar Antonio Abreu de Souza, Michelle Rosa Andrade Alves, Rosangelis del Lama Soares, Viviane de Cássia Kanufre, Valéria de Melo Rodrigues, Rocksane de Carvalho Norton, Ana Lúcia Pimenta Starling, Marcos José Burle de Aguiar   +7 more
doaj   +1 more source

Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures

, 2011
Background: Various effects on pain have been reported with respect to their statistical significance, but a standardized measure of effect size has been rarely added.
Karin Flühr, Doehring Alexandra, Flühr, Karin, Küsener, Nele, Jörn Lötsch, Doehring, Alexandra, Küsener Nele, Alexandra Doehring, Flühr Karin, Nele Küsener, Till J Neddermeyer, Lötsch Jörn, Neddermeyer, Till, Lötsch, Jörn, Neddermeyer Till J., Schneider, Gaby, Till J. Neddermeyer, Gaby Schneider, Schneider Gaby   +18 more
core   +1 more source

Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio

Pteridines, 2013
The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the production of neopterin in human monocytic cells and of 5,6,7,8-tetrahydrobiopterin (BH4) in other human cells and cells of other species is markedly upregulated.
Geisler Simon, Gostner Johanna M., Becker Kathrin, Ueberall Florian, Fuchs Dietmar   +4 more
doaj   +1 more source

GTP Cyclohydrolase I Phosphorylation and Interaction With GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide

, 2010
Rationale: GTP cyclohydrolase I (GTPCH-1) is the rate-limiting enzyme involved in de novo biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for NO synthases and aromatic amino acid hydroxylases.
Kwon, Kihwan, Harrison, David G., Chen, Wei, Li, Li, Salerno, John C., Rezvan, Amir, Jo, Hanjoong, Husain, Ahsan   +7 more
core   +1 more source

Capsaicin Inhibits Biofilm and Its Related Functions in Helicobacter pylori

Microorganisms
Background: Helicobacter pylori is a globally prevalent gastric pathogen associated with chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma.
Khalid I. AlHussaini, Razique Anwer
doaj   +1 more source