Results 101 to 110 of about 4,605 (211)

GTP cyclohydrolase II structure and mechanism

GTP cyclohydrolase II converts GTP to 2,5-diamino-6-β-ribosyl-4(3N)- pyrimidinone 5′-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis.
Kotaka M, Lockyer M, Lamb HK, Ren J, Stammers DK, Hawkins AR   +5 more
core  

Induction of GTP-cyclohydrolase I mRNA expression by lectin activation and interferon-γ treatment in human cells associated with the immune response.

, 1993
The development of tetrahydrobiopterin synthesis during lectin stimulation of resting human T lymphocytes (Kerler et al. [1989] FEBS Lett., 250:622-624), the interferon-γ induced neopterin production by human monocytes/macrophages (Huber et al ...
Gütlich, M., Schott, K., Ziegler, I.
core  

Cross-species RNAi therapy via AAV delivery alleviates neuropathic pain by targeting GCH1

Neurotherapeutics
Tetrahydrobiopterin (BH4) expression is normally strictly controlled; however, its intracellular levels increase considerably following nerve damage. GTP cyclohydrolase I (GCH1) plays a crucial role in regulating BH4 concentration, with an upregulation ...
Heesue Chang, Kyoung Jin Lee, Minkyung Park, Ha-Na Woo, Ji Hyun Kim, Im Kyeung Kang, Hyochan Park, Chan Hee Chon, Heuiran Lee, Hyun Ho Jung   +9 more
doaj   +1 more source

Neopterin and Nitrite in Supernatants from Interferon-γ-treated Monocytoid Cell Lines: A Tool to Identify Bacterial Pyrogens

Pteridines, 1999
The rabbit pyrogen assay identifies pyrogenic contaminations in drugs i.l1tend~d for parenteral use. In order to replace this test because of ethical and economical reasons, various in vitro methods have been developed in recent years. Here, we summarize
Peterbauer Anja, Werner Ernst R., Werner-Felmayer Gabriele   +2 more
doaj   +1 more source

GTP cyclohydrolase I activity from Rickettsia monacensis strain Humboldt, a rickettsial endosymbiont of Ixodes pacificus. [PDF]

Ticks Tick Borne Dis, 2020
Bodnar J, Fitch S, Sanchez J, Lesser M, Baston DS, Zhong J.   +5 more
europepmc   +1 more source

On the mechanism of action of GTP-transforming enzymes

, 1997
Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discussed in the context of the crystal structure of the GTP cyclohydrolase I - 2'-deoxy-GTP complex.
Dufton, Mark J., Athmani, Salah, Andrew R. Pitt, Gibson, Colin L., Salah Athmani, Colin J. Suckling, Suckling, Colin J., Mark J. Dufton, Colin L. Gibson, Pitt, Andrew R.; id_orcid   +9 more
core   +1 more source

GTP cyclohydrolase I deficiency [PDF]

, 2020
openaire   +3 more sources

Pain Genetics and Personalized Spine Care

Global Spine Journal, 2014
Spine pain (SP), such as low back pain, is among the most common musculoskeletal disorders and is the single most common disorder causing disability in industrialized countries.
Inna Belfer
doaj   +1 more source

Mechanism and Catalytic Strategy of the Prokaryotic Specific GTP Cyclohydrolase IB

, 2017
GTP cyclohydrolase I catalyzes the first step in folic acid biosynthesis in bacteria and plants, biopterin biosynthesis in mammals, and the biosynthesis of 7-deazaguanosine modified tRNA nucleosides in bacteria and archaea. The type IB GTP cyclohydrolase
Iwata-Reuyl, Dirk, Alvarez, Jonathan, Luthra, Amit, Paranagama, Naduni, Swairjo, Manal A., Stec, Boguslaw, Bonnett, Shilah A., Gustafson, Andrew   +7 more
core   +1 more source

GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: Identification and functional characterization of four novel mutations

, 2004
GTP-cyclohydrolase I (GTP-CH1, EC 3.5.4.16) is encoded by the GCH1 gene. Mutations in the GCH1 gene cause both dopa-responsive dystonia (McKusick 128230) and recessive GTP-CH1 deficiency (McKusick 600225).
Viscardi V., Ghezzi D., Zorzi G., Saracino F., Nardocci N., Garavaglia B., Carbone M. L. A., Invernizzi F., Zeviani M.   +8 more
core   +1 more source