Results 111 to 120 of about 4,605 (211)

Evolution of New Function in the GTP Cyclohydrolase II Proteins of Streptomyces coelicolor^†

, 2016
The genome sequence of Streptomyces coelicolor contains three open reading frames (sco1441, sco2687, and sco6655) that encode proteins with significant (>40%) amino acid identity to GTP cyclohydrolase II (GCH II), which catalyzes the committed step in ...
Annie L. Dahlgran (2525758), Vahe Bandarian (1235361), James E. Spoonamore (2452612), Neil E. Jacobsen (477784)   +3 more
core   +1 more source

Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines

, 1998
Proinflammatory cytokines, a combination of IL-1β, TNF-α, and IFN-γ, caused mRNA expression of GTP cyclohydrolase I (GTP-CH), the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, and of inducible nitric oxide synthase (iNOS) in a well ...
Toshiharu Nagatsu, Makio Mogi, Arai, Michitsugu, Kondo, Ayami, Mogi, Makio, Nagatsu, Toshiharu, Akifumi Togari, Togari, Akifumi, Michitsugu Arai, Ayami Kondo   +9 more
core   +1 more source

Subklonirovanie i issledovanie gena GTP-tsiklogidrolazy Bacillus subtilis.

, 1991
International audienceBacillus subtilis GTP-cyclohydrolase gene and its deletion derivatives were subcloned in Escherichia coli cells. The position of the gene within the riboflavine operon was defined.
Batchikova, N V, Bidnenko, Vladimir E, Boretskiĭ, Iu R, Drobinskaia, I E, Rabinovich, P M   +4 more
core  

A splice mutation in the GTP cyclohydrolase I gene causes dopa‐responsive dystonia by exon skipping

, 2001
Four different mutations in the GTP cyclohydrolase I gene were found (P199L, M211V, IVS5+1G>A, G203R) in 6 out of 33 families with dopa-responsive dystonia.
M. Skrygan, K. Bartholomé, Bartholome, B., Bonafe, L., N. Blau, Skrygan, M., L. Bonafé, Blau, N., Bartholome, K., B. Bartholomé   +9 more
core   +1 more source

BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia,

Jornal de Pediatria
Objectives To show the general prevalence and to characterize tetrahydrobiopterin (BH4) deficiencies with hyperphenylalaninemia, identified by the Neonatal Screening Program of the State of Minas Gerais.
Cezar Antonio Abreu de Souza, Michelle Rosa Andrade Alves, Rosangelis del Lama Soares, Viviane de Cássia Kanufre, Valéria de Melo Rodrigues, Rocksane de Carvalho Norton, Ana Lúcia Pimenta Starling, Marcos José Burle de Aguiar   +7 more
doaj   +1 more source

Dopa-Responsive Dystonia Induced by a Recessive Gtp Cyclohydrolase I

, 2008
GTP cyclohydrolase I (GTPCH) catalyzes the rate-limiting step of tetrahydrobiopterin (BH4) biosynthesis. GTPCH has been associated with two clinically distinct human diseases: the recessive hyperphenylalaninemia ( HPA) and the dominant dopa-responsive ...
HWU, WUH-LIANG, 胡務亮
core  

Hormonal control of GTP cyclohydrolase I gene expression and enzyme activity during color pattern development in wings of Precis coenia.

, 2002
Color patterns of butterfly wings are composed of single color points represented by each scale. In the case of Precis coenia, at the end of pupal development, different types of pigments are synthesized sequentially in the differently colored scales ...
H Sawada, Reinhardt, R.K., M Nakagoshi, Ziegler, I., R K Reinhardt, I Ziegler, Sawada, H., Nakagoshi, M., P B Koch, Koch, P.B.   +9 more
core  

A New Use for a Familiar Fold:  The X-ray Crystal Structure of GTP-Bound GTP Cyclohydrolase III from Methanocaldococcus jannaschii Reveals a Two Metal Ion Catalytic Mechanism^†,‡

, 2016
GTP cyclohydrolase (GCH) III from Methanocaldococcus jannaschii, which catalyzes the conversion of GTP to 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5‘-phosphate (FAPy), has been shown to require Mg2+ for catalytic activity and is activated ...
William R. Montfort (1350579), Vahe Bandarian (1235361), Shane D. Morrison (195468), Sue A. Roberts (1528186), Abreeza M. Zegeer (2459869)   +4 more
core   +1 more source

Biochemical defect of the hph-1 mouse mutant is a deficiency in GTP-cyclohydrolase activity

, 1988
Click on the link to access the article (may not be free).A hyperphenylalaninemic mouse mutant, hph-1, has been identified in the progeny of mice treated with the mutagen ethylnitrosourea. Phenylalanine hydroxylase activity levels in mutant liver lysates
Ledley, F.D., Bode, Vernon C., Jennings, I., Cotton, R.G., Woo, S.L., McDonald, J. David   +5 more
core  

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms

, 2008
We describe a unique presentation of autosomal recessive (AR) GTP cyclohydrolase I (GTPCH) deficiency, with severe CNS involvement but without hyperphenylalaninemia.
Rupar, T, Horvath, G A, Stockler-Ipsiroglu, S G, Lillquist, Y P, Connolly, M, Salvarinova-Zivkovic, R, Hyland, K, Blau, N, Waters, P J   +8 more
core   +1 more source