Results 51 to 60 of about 4,605 (211)
Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse [PDF]
Free Radical Biology and Medicine, 2011 Tetrahydrobiopterin (BH4) is a regulator of endothelial nitric oxide synthase (eNOS) activity. Deficient levels result in eNOS uncoupling, with a shift from nitric oxide to superoxide generation. The hph-1 mutant mouse has deficient GTP cyclohydrolase I (GTPCH1) activity, resulting in low BH4 tissue content.
Jaques, Belik +5 more
openaire +2 more sources
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal +6 more
wiley +1 more source
Pteridines, 1997 Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata ...
Sakamoto Hideo +2 more
doaj +1 more source
A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ +8 more
wiley +1 more source
Primers and probes for GTP-cyclohydrolase I mRNA reverse transcriptase polymerase chain reaction.
, 2015 Primers and probes for GTP-cyclohydrolase I mRNA reverse transcriptase polymerase chain reaction.
J. Brice Weinberg (271620) +10 more
core +1 more source
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source
, 1999 Saccharomyces cerevisiae is so far the only organism where a knock-out mutant in the gene encoding GTP cyclohydrolase I (FOL2) has been obtained. GTP cycloydrolase I controls the de novo biosynthetic pathway of tetrahydrobiopterin and folic acid.
A. Bracher +8 more
core +1 more source
Cell Proliferation, Volume 59, Issue 5, May 2026.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others [PDF]
, 1988 The first enzyme in pteridine biosynthesis, GTP cyclohydrolase I, is a likely site for regulation of pteridine biosynthesis to occur. GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based ...
Jacobson, K. Bruce, Manos, Richard E.
core
, 1996 Gene transfer of tyrosine hydroxylase (TH) in animal models of Parkinson’s disease (PD), using either genetically modified cells or recombinant virus vectors, has produced partial restoration of behavioral and biochemical deficits. The limited success of
Kazuyuki Hatakeyama +5 more
core +1 more source