Results 31 to 40 of about 4,605 (211)

GTP cyclohydrolase II structure and mechanism.

, 2005
GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis.
Ren, J, Stammers, DK, Lockyer, M, Hawkins, AR, Kotaka, M, Lamb, HK   +5 more
core   +1 more source

Decameric GTP Cyclohydrolase I Forms Complexes with Two Pentameric GTP Cyclohydrolase I Feedback Regulatory Proteins in the Presence of Phenylalanine or of a Combination of Tetrahydrobiopterin and GTP [PDF]

Journal of Biological Chemistry, 1998
The activity of GTP cyclohydrolase I is inhibited by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) and stimulated by phenylalanine through complex formation with GTP cyclohydrolase I feedback regulatory protein (GFRP). Gel filtration experiments as well as enzyme activity measurements showed that the number of subunits of GFRP in both the inhibitory
T, Yoneyama, K, Hatakeyama
openaire   +2 more sources

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Pteridines, 1998
The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi, Sakamoto Hideo, Fujita Ko   +2 more
doaj   +1 more source

Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity

, 1994
Click on the DOI link to access the article (may not be free).GTP cyclohydrolase I catalyzes the initial and rate limiting step of the biosynthesis of tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylation.
Witter, K., Hultner, L., Ziegler, I., Gutlich, M., Werner, T., Bacher, A., Hemmens, B., McDonald, J. David, Rodl, W.   +8 more
core   +1 more source

Troglitazone Stimulates the Insulin-induced Tetrahydrobiopterin Synthesis In Vascular Endothelial Cells

Pteridines, 2000
We investigated the effects of troglitazone, which is a ligand of nuclear transcription factor peroxisome proliferator- activated receptor-γ (PPAR-γ), on insulin-induced tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells ...
Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells

, 1998
—In vascular endothelial cells, tetrahydrobiopterin serves as an essential cofactor required for enzymatic activity of nitric oxide synthase. GTP cyclohydrolase I is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin.
Zvonimir S. Katusic, Sheldon Milstien, Adele Stelter   +2 more
core   +1 more source

Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 1999
We examined the effects of insulin on tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells (MBMECs). Treatment of MBMECs with insulin increased the intracellular BH4 content in a time- and concentration-dependent manner. The
Ishi Masakazu, Shimizu Shunichi, Nagai Tsutomu, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Polymorphism of Antifolate Drug Resistance in Plasmodium vivax From Local Residents and Migrant Workers Returned From the China-Myanmar Border

Frontiers in Cellular and Infection Microbiology, 2021
Drug-resistant Plasmodium vivax malaria impedes efforts to control, eliminate, and ultimately eradicate malaria in Southeast Asia. P. vivax resistance to antifolate drugs derives from point mutations in specific parasite genes, including the ...
Weilin Zeng, Siqi Wang, Shi Feng, Daibin Zhong, Yue Hu, Yao Bai, Yonghua Ruan, Yu Si, Hui Zhao, Qi Yang, Xinxin Li, Xi Chen, Yanmei Zhang, Cuiying Li, Zheng Xiang, Yanrui Wu, Fang Chen, Pincan Su, Benjamin M. Rosenthal, Zhaoqing Yang   +19 more
doaj   +1 more source

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source