Results 21 to 30 of about 4,605 (211)

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Biomolecules, 2021
Members of the DUF34 (domain of unknown function 34) family, also known as the NIF3 protein superfamily, are ubiquitous across superkingdoms. Proteins of this family have been widely annotated as “GTP cyclohydrolase I type 2” through electronic ...
Colbie J. Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard   +2 more
doaj   +1 more source

Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Pteridines, 1998
Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine ...
Hattori Yoshiyuki, Nakanishi Nobuo, Gross Steven S., Kasai Kikuo   +3 more
doaj   +1 more source

Biosynthetic Enzymes of Tetrahydrolimipterin from Green Sulfur Bacterium Chlorobium Limicola

Pteridines, 1998
Based on the structure of limipterin (Cha, Pfleiderer, and Yim, Helv, Chim. Acta, 78: 600-614. 1995 the biosynthetic pathway for the newly identified pterin glycoside was investigated. It was demonstrated that tetrahydrolimipterin (H4 -limipterin) can be
Kang Dongmin, Kim Sangjoon, Yim Jeongbin
doaj   +1 more source

Preparation of Isotope-labeled Dihydroneopterin 3'-Triphosphate with High Specific Activity

Pteridines, 1990
Isotope-labeled dihydroneopterin 3'-triphosphate with 3H at positions C-1' and C-2', respectively, has been prepared from isotope-labeled glucose as starting material. Glucose was first converted enzymatically to ribose 5-phosphate.
Katzenmeier Gerd, Schwarzkopf Bruno, Van Quang Le, Schmid Cornelia, Bacher Adelbert   +4 more
doaj   +1 more source

Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease

Pteridines, 1999
Both neopterin and biopterin concentrations in cerebrospinal fluid from patients with Parkinson's disease, in which the nigrostriatal dopamine neurons degenerate, were lower than those from age-matched older control subjects.
Nagatsu T., Ichinose H., Mogi M., Togari A.   +3 more
doaj   +1 more source

Co-Overexpression of RIB1 and RIB6 Increases Riboflavin Production in the Yeast Candida famata

Fermentation, 2022
Riboflavin or vitamin B2 is a water-soluble vitamin and a precursor of flavin coenzymes, flavin mononucleotide, and flavin adenine dinucleotide, which play a key role as enzyme cofactors in energy metabolism.
Yana Petrovska, Oleksii Lyzak, Justyna Ruchala, Kostyantyn Dmytruk, Andriy Sibirny   +4 more
doaj   +1 more source

A Putative Guanosine Triphosphate Cyclohydrolase I Named CaGCH1 Is Involved in Hyphal Branching and Fruiting Development in Cyclocybe aegerita

Frontiers in Microbiology, 2022
Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) is the limiting enzyme of the tetrahydrobiopterin (BH4) synthesis pathway. The disruption of gch1 gene may cause conditional lethality due to folic acid auxotrophy in microorganisms, although the ...
Nan Tao, Nan Tao, Nan Tao, Bopu Cheng, Bopu Cheng, Hongmei Chai, Hongmei Chai, Hongmei Chai, Xianghua Cui, Xianghua Cui, Xianghua Cui, Yuanhao Ma, Yuanhao Ma, Yuanhao Ma, Jinping Yan, Yongchang Zhao, Yongchang Zhao, Yongchang Zhao, Weimin Chen, Weimin Chen, Weimin Chen   +20 more
doaj   +1 more source

Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene

Pteridines, 1995
We have isolated genomic clones that contained the gene for human GTP cyclohydrolase I. One clone containing the 5'-regulatory region of this gene was further analysed.
Gütlich Markus, Witter Klaus, Katzenmeier Gerd, Rödl Wolfgang, Wernert Thomas, Ziegler Irmgard, Bacher Adelbert   +6 more
doaj   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells

Pteridines, 2003
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi, Miyasaka Yoshiyuki, Yamamoto Shinichiro, Ishii Masakazu, Kiuchi Yuji   +4 more
doaj   +1 more source

Statin Increases GTP Cyclohydrolase I mRNA and 5,6,7,8-Tetrahydrobiopterin in Vascular Endothelial Cells

Pteridines, 2006
We investigated the effects of HMG-CoA reductase inhibitors, so-called statins, on 5,6,7,8-tctrahydrobioptcrin (BH4) metabolism in human umbilical vein endothelial cells (HUVEC).
Hattori Yoshiyuki, Nakanishi Nobuo
doaj   +1 more source