Results 11 to 20 of about 4,605 (211)

Reduction of GTP Cyclohydrolase I Feedback Regulating Protein Expression by Hydrogen Peroxide in Vascular Endothelial Cells

Journal of Pharmacological Sciences, 2005
We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and ...
Masakazu Ishii, Shunichi Shimizu, Teruaki Wajima, Tamio Hagiwara, Takaharu Negoro, Akira Miyazaki, Takashi Tobe, Yuji Kiuchi   +7 more
doaj   +2 more sources

GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus. [PDF]

PLoS ONE, 2014
The genetic background of atherosclerosis in type 2 diabetes mellitus (T2DM) is complex and poorly understood. Studying genetic components of intermediate phenotypes, such as endothelial dysfunction and oxidative stress, may aid in identifying novel ...
Pawel P Wolkow, Wladyslaw Kosiniak-Kamysz, Grzegorz Osmenda, Grzegorz Wilk, Beata Bujak-Gizycka, Adam Ignacak, Mihir Kanitkar, Malgorzata Walus-Miarka, David G Harrison, Ryszard Korbut, Maciej T Malecki, Tomasz J Guzik   +11 more
doaj   +2 more sources

cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells

Journal of Pharmacological Sciences, 2003
: Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) catalysis of ...
Hiroaki Shiraishi, Taiya Kato, Koji Atsuta, Chiho Sumi-Ichinose, Masatsugu Ohtsuki, Mitsuyasu Itoh, Hitoshi Hishida, Shin Tada, Yasuhiro Udagawa, Toshiharu Nagatsu, Yasumichi Hagino, Hiroshi Ichinose, Takahide Nomura   +12 more
doaj   +2 more sources

Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. [PDF]

Arterioscler Thromb Vasc Biol, 2009
Objective— The posttranslational regulation of GTP cyclohydrolase I (GCH-1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, remains elusive. Here, we identified specific phosphorylation sites on GCH-1 and characterized the function of these sites.
Du J, Wei N, Xu H, Ge Y, Vásquez-Vivar J, Guan T, Oldham KT, Pritchard KA, Shi Y.   +8 more
europepmc   +4 more sources

Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism [PDF]

Neurobiology of Disease, 2011
The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and function.
Faiza Ferdousy, William Bodeen, Kyle Summers, Olugbenga Doherty, O'Neil Wright, Nahed Elsisi, George Hilliard, Janis M. O'Donnell, Lawrence T. Reiter   +8 more
doaj   +2 more sources

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.

The Journal of biological chemistry, 1995
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Matsumoto, S., Fujita, K., and Nagatsu, T. (1992) Biochem. Biophys. Res. Commun. 187, 359-365).
Ichinose H, Ohye T, Matsuda Y, Hori T-A, Blau N, Burlina A, Rouse B, Matalon R, Fujita K, Nagatsu T   +9 more
openaire   +5 more sources

Do genetic predictors of pain sensitivity associate with persistent widespread pain? [PDF]

, 2009
Genetic risk factors for pain sensitivity may also play a role in susceptibility to chronic pain disorders, in which subjects have low pain thresholds.
Nicholl Barbara I, McBeth John, Davies, K.A., Macfarlane, Gary J., John McBeth, Holliday, K.L., Kate L Holliday, Nicholl, Barbara I., Thomson, W., Macfarlane, G.J., Thomson Wendy, Nicholl, B.I, Davies Kelly A, McBeth, J., Holliday, Kate L., McBeth, John, Wendy Thomson, Kelly A Davies, Macfarlane Gary J, Holliday Kate L, Thomson, Wendy, Gary J Macfarlane, Barbara I Nicholl, Davies, Kelly A.   +23 more
core   +1 more source

Tetrahydrobiopterin Plays a Functionally Significant Role in Lipogenesis in the Oleaginous Fungus Mortierella alpina

Frontiers in Microbiology, 2020
Tetrahydrobiopterin (BH4) is well-known as a cofactor of phenylalanine hydroxylase (PAH) and nitric oxide synthase (NOS), but its exact role in lipogenesis is unclear.
Hongchao Wang, Hongchao Wang, Chen Zhang, Chen Zhang, Haiqin Chen, Haiqin Chen, Zhennan Gu, Zhennan Gu, Jianxin Zhao, Jianxin Zhao, Hao Zhang, Hao Zhang, Hao Zhang, Yong Q. Chen, Yong Q. Chen, Yong Q. Chen, Wei Chen, Wei Chen, Wei Chen   +18 more
doaj   +1 more source

GTP cyclohydrolase I utilizes metal‐free GTP as its substrate [PDF]

European Journal of Biochemistry, 2003
GTP cyclohydrolase I (GCH) is the rate‐limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. We have studied the action of divalent cations on the enzyme activity of purified recombinant human GCH expressed in Escherichia ...
T. Suzuki, H. Kurita, H. Ichinose
openaire   +2 more sources

Homology Cloning of GTP-cydohydrolase I from Fungi and Plants by Reverse-transcription PCR Using a General Set of Degenerate Primers

Pteridines, 1995
Unconjugated pteridines are present in fungi, algae and plants. However, the functions of pteridines in these organisms are not thoroughly investigated. The biosynthesis follows the same steps as were shown for animals and eubacteria.
Maier Josef, Werner Thomas, Ninnemann Helga   +2 more
doaj   +1 more source