Results 141 to 150 of about 261,647 (345)
The Journal of Cell Biology, 2000 The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti 1999). ECM components can signal directly to cells through transmembrane receptors such as integrins, and can also present soluble cytokines and growth factors to ...
openaire +3 more sources
Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source
Advanced Science, EarlyView.KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma +9 more
wiley +1 more source
A Rho-actin signaling pathway shapes cell wall boundaries in Arabidopsis xylem vessels
Nature Communications, 2019 Cell wall pits allow movement of water between xylem vessels and are formed via Rho-GTPase mediated signaling that leads to local microtubule disassembly. Here, Sugiyama et al.
Yuki Sugiyama +6 more
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, 2011 GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Anja Höfle +45 more
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Advanced Science, EarlyView.This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao +8 more
wiley +1 more source
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Nature Communications, 2019 Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II regions ...
Yoshihito Kano +18 more
doaj +1 more source
Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. [PDF]
, 2019 Cells have evolved diverse protein-based machinery to reshape, cut, or fuse their membrane-delimited compartments. Dynamin superfamily proteins are principal components of this machinery and use their ability to hydrolyze GTP and to polymerize into ...
Frost, Adam, Kalia, Raghav
core
Advanced Science, EarlyView.Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan +19 more
wiley +1 more source