Results 41 to 50 of about 278,687 (359)
Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core +1 more source
Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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Fixing the GAP: The role of RhoGAPs in cancer
European Journal of Cell Biology, 2022 Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman +2 more
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Turing instabilities in a mathematical model for signaling networks
, 2011 GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev +27 more
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DNM1 encephalopathy: A new disease of vesicle fission. [PDF]
, 2017 ObjectiveTo evaluate the phenotypic spectrum caused by mutations in dynamin 1 (DNM1), encoding the presynaptic protein DNM1, and to investigate possible genotype-phenotype correlations and predicted functional consequences based on structural modeling ...
Campbell, Colleen A +38 more
core +2 more sources
Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast
Scientific Reports, 2017 The final step in post-translational processing of Ras and Rho GTPases involves methylation of the prenylated cysteine residue by an isoprenylcysteine-O-carboxyl methyltransferase (ICMT).
Alejandro Franco +9 more
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The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory
Frontiers in Synaptic Neuroscience, 2020 The ability to form memories in the brain is needed for daily functions, and its impairment is associated with human mental disorders. Evidence indicates that long-term memory (LTM)-related processes such as its consolidation, extinction and forgetting ...
Joana Freitas Costa +2 more
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Veterinary Research, 2023 The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies, responsible for severe economic losses to the swine industry worldwide.
Xiaohua Zhang +7 more
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Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation
Frontiers in Cellular and Infection Microbiology, 2022 Irgb6 is a member of interferon γ-induced immunity related GTPase (IRG), and one of twenty “effector” IRGs, which coordinately attack parasitophorous vacuole membrane (PVM), causing death of intracellular pathogen.
Hiroshi Yamada +6 more
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