Results 11 to 20 of about 15,901 (303)
Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency [PDF]
Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-
Abdelkader A. Metwally +1 more
doaj +4 more sources
Advanced glycation end products mediate biomineralization disorder in diabetic bone disease [PDF]
Summary: Patients with diabetes often experience fragile fractures despite normal or higher bone mineral density (BMD), a phenomenon termed the diabetic bone paradox (DBP).
Qianmin Gao +24 more
doaj +2 more sources
Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols [PDF]
In an attempt to create models of phosphodiesterases, we previously investigated bis(guanidinium) naphthols. Such metal‐free anion receptors cleaved aryl phosphates and also plasmid DNA.
Catharina Kost +3 more
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Mechanistic DFT Study of 1,3-Dipolar Cycloadditions of Azides with Guanidine
Density functional calculations SMD(chloroform)//B3LYP/6-311+G(2d,p) were employed in the computational study of 1,3-dipolar cycloadditions of azides with guanidine.
Ivana Antol +2 more
doaj +1 more source
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets.
Marek Staszewski +12 more
doaj +1 more source
A small library of substituted cyclic guanidine incorporated benzothiazole-6-sulphonamides was synthesized. All obtained compounds were investigated for their inhibitory activity against the key brain-associated human carbonic anhydrase isoform hCA VII ...
Morteza Abdoli +2 more
doaj +1 more source
Guanidinates as Alternative Ligands for Organometallic Complexes
For decades, ligands such as phosphanes or cyclopentadienyl ring derivatives have dominated Coordination and Organometallic Chemistry. At the same time, alternative compounds have emerged that could compete either for a more practical and accessible ...
Fernando Carrillo-Hermosilla +3 more
doaj +1 more source
Amino Acylguanidines as Bioinspired Catalysts for the Asymmetric Aldol Reaction
The binding and stabilizing effect of arginine residues in certain aldolases served as inspiring source for the development of a family of amino acylguanidine organocatalysts.
Ciril Jimeno
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Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus Leishmania. In the search for newer, safer, and more effective antileishmanial compounds, we herein present a study of the mode of action in addition to
Vitor Partite Moreira +19 more
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Galega officinalis L. has been known for centuries as an herbal medicine used to alleviate the symptoms of diabetes, but its comprehensive chemical composition and pharmacological activity are still insufficiently known.
Katarzyna Bednarska +2 more
doaj +1 more source

