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Flipping Back of Extrahelical Guanine after Methyl Repair
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala +1 more
doaj +3 more sources
Gut and Liver, 2020 Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF).
Young Youn Cho +8 more
doaj +1 more source
Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate
Acta Crystallographica Section E: Crystallographic Communications, 2023 The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
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A new possible way for cancer cure – DNA four strand [PDF]
World Cancer Research Journal, 2019 DNA is the active ingredient of all the biological operations of the cell because it stores genetic information in the configuration of genes. It is a very well recognized fact that DNA has a double-helical structure; recently, it was reported to have ...
P. Amit, K. Prerna, S. Anita, S. Kumar
doaj +1 more source
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
core +1 more source
Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core +1 more source
Application of Ammonium Persulfate for Selective Oxidation of Guanines for Nucleic Acid Sequencing
Molecules, 2017 Nucleic acids can be sequenced by a chemical procedure that partially damages the nucleotide positions at their base repetition. Many methods have been reported for the selective recognition of guanine.
Yafen Wang +7 more
doaj +1 more source
G-quartet biomolecular nanowires
, 2002 We present a first-principle investigation of quadruple helix nanowires, consisting of stacked planar hydrogen-bonded guanine tetramers. Our results show that long wires form and are stable in potassium-rich conditions.
Calzolari, A. +3 more
core +1 more source
An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
core +2 more sources
IUCrJ, 2018 This paper presents experimental charge-density studies of cytosinium chloride, adeninium chloride hemihydrate and guaninium dichloride crystals based on ultra-high-resolution X-ray diffraction data and extensive theoretical calculations.
Prashant Kumar +3 more
doaj +1 more source