Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin [PDF]
Biomolecules, 2022 Guanine nucleotides can flip between a North and South conformation in the ribose moiety. To test the enzymatic activity of GTPases bound to nucleotides in the two conformations, we generated methanocarba guanine nucleotides in the North or South ...
Kiran S. Toti +4 more
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Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase [PDF]
Biomolecules, 2022 The final maturation step of the 60S ribosomal subunit requires the release of eukaryotic translation initiation factor 6 (human eIF6, yeast Tif6) to enter the pool of mature ribosomes capable of engaging in translation.
Jesús Pérez-Juárez +3 more
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Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. [PDF]
PLoS ONE, 2014 In this study, we compared the influence of GDP and GTP on isolated mitochondria respiring under conditions favoring oxidative phosphorylation (OXPHOS) and under conditions excluding this process, i.e., in the presence of carboxyatractyloside, an adenine
Andrzej M Woyda-Ploszczyca +1 more
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Determination of the Global Pattern of Gene Expression in Yeast Cells by Intracellular Levels of Guanine Nucleotides [PDF]
mBio, 2019 Correlations between gene transcription and the abundance of high-energy purine nucleotides in Saccharomyces cerevisiae have often been noted. However, there has been no systematic investigation of this phenomenon in the absence of confounding factors ...
Andy Hesketh +2 more
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RNA structural probing of guanine and uracil nucleotides in yeast.
PLoS ONE, 2023 RNA structure can be essential for its cellular function. Therefore, methods to investigate the structure of RNA in vivo are of great importance for understanding the role of cellular RNAs.
Kevin Xiao +2 more
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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. [PDF]
PLoS ONE, 2011 Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain.
Jean-Marc Taymans +7 more
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Molecules, 2022 The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the
Kim Tiedemann +2 more
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AMB Express, 2020 The giant mottled eel is a species with high commercial value so overfishing, river management, and water pollution have negatively affected its movement and population numbers. Anguilla marmorata (eel) was listed in the Vietnam Red Data Book 2007 with a
Kieu Thi Huyen, Nguyen Quang Linh
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Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
Nature Communications, 2021 Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ...
Hongxu Ding +4 more
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]
PLoS Pathogens, 2010 Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher +5 more
doaj +1 more source