Results 251 to 260 of about 104,742 (325)

Base excision repair within structure-forming repeat sequences and its impact on cancer and other diseases. [PDF]

NAR Cancer
Cohen CB, Coombes MC, Merlo CP, Kontor CA, Meah R, Whitaker AM.   +5 more
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

The mechanism of thioamide formation by the YcfA-YcfC system in 6-thioguanine biosynthesis. [PDF]

Nat Commun
Zhang L, Dou C, Yan W, Chen P, Jia X, Zhang N, Zhou D, Long Z, Zhang L, Zhu X, Cheng W.   +10 more
europepmc   +1 more source

TC-PTP Dephosphorylates the Guanine Nucleotide Exchange Factor C3G (RapGEF1) and Negatively Regulates Differentiation of Human Neuroblastoma Cells

, 2011
Aninda Mitra, Srinivasan Kalayarasan, Vijay Gupta, Vegesna Radha   +3 more
openalex   +2 more sources

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Large-Scale Conformational Analysis Explains G-Quadruplex Topological Landscape. [PDF]

J Phys Chem B
Jurkowski M, Kogut M, Olewniczak M, Glinko J, Czub J.   +4 more
europepmc   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA. [PDF]

Nucleic Acids Res
Cox LB, Mattick JS, Middleton IA, Rizzuto FJ, Thordarson P.   +4 more
europepmc   +1 more source

The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in Neurospora crassa

, 2012
Carla J. Eaton, Ilva E. Cabrera, Jacqueline A. Servin, Sara J. Wright, Murray P. Cox, Katherine A. Borkovich   +5 more
openalex   +2 more sources

Epigenetic Age Estimation for Hawaiian False Killer Whales (Pseudorca crassidens) in the Absence of ‘Known‐Age’ Individuals

Molecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT Epigenetic aging models hold great promise for enhancing many aspects of wildlife research and management. However, their utility is limited by the need to train models using known‐aged animals, which are rare among wildlife species. We present a novel approach to developing methylation‐based age prediction models that enables us to train ...
Karen K. Martien, Robin W. Baird, Kelly M. Robertson, Michaela A. Kratofil, Sabre D. Mahaffy, Kristi L. West, Susan J. Chivers, Frederick I. Archer   +7 more
wiley   +1 more source