Results 31 to 40 of about 99,476 (367)
Are guanine nucleotide binding proteins a distinct class of regulatory proteins? [PDF]
, 1983 Proteins which bind guanine nucleotides are found in a diverse set of key regulatory positions. They are involved in hormone action, visual transduction, protein synthesis and microtubule assembly. In addition to their ability to bind guanine nucleotides
Kleinzeller +49 more
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Nature Communications, 2016 Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical ...
Malgorzata Dobosz-Bartoszek +6 more
doaj +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core +1 more source
Chromatin structure and context-dependent sequence features control prime editing efficiency
Frontiers in Genetics, 2023 Prime editing (PE) is a highly versatile CRISPR–Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization.
Somang Kim +15 more
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Distributions of Bubble Lifetimes and Bubble Lengths in DNA [PDF]
Phys. Rev. E 102, 062114 (2020), 2020 We investigate the distribution of bubble lifetimes and bubble lengths in DNA at physiological temperature, by performing extensive molecular dynamics simulations with the Peyrard-Bishop-Dauxois (PBD) model, as well as an extended version (ePBD) having a sequence-dependent stacking interaction, emphasizing the effect of the sequences' guanine-cytosine (
arxiv +1 more source
SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
eLife, 2022 Viral infection involves complex set of events orchestrated by multiple viral proteins. To identify functions of SARS-CoV-2 proteins, we performed transcriptomic analyses of cells expressing individual viral proteins.
Michela Zaffagni +5 more
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Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein α Subunits in Go, G11, and G16 [PDF]
, 2000 We previously reported that the xanthine nucleotide binding Goα mutant, GoαX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11α and G16α and characterized their nucleotide binding and receptor interaction.
Gu, Lingjie, Simon, Melvin I., Yu, Bo
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Trapp Stimulates Guanine Nucleotide Exchange on Ypt1p [PDF]
The Journal of Cell Biology, 2000 TRAPP, a novel complex that resides on early Golgi, mediates the targeting of ER-to-Golgi vesicles to the Golgi apparatus. Previous studies have shown that YPT1, which encodes the small GTP-binding protein that regulates membrane traffic at this stage of the secretory pathway, interacts genetically with BET3 and BET5.
Susan Ferro-Novick +2 more
openaire +3 more sources
Dampening of neurotransmitter action: molecular similarity within the melatonin structure
Endocrine Regulations, 2018 Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
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Mechanisms for DNA Charge Transport [PDF]
, 2010 DNA charge transport (CT) chemistry has received considerable attention by scientific researchers over the past 15 years since our first provocative publication on long range CT in a DNA assembly.1,2 This interest, shared by physicists, chemists and ...
Barton, Jacqueline K. +1 more
core +2 more sources