Results 1 to 10 of about 852,730 (306)

The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life

BMC Pediatrics, 2021
Background The early life period represents the first step in establishing a beneficial microbial ecosystem, which in turn affects both short and longer-term health.
Sarah Phillips, Rachel Watt, Thomas Atkinson, George M Savva, Antonietta Hayhoe, Lindsay J Hall, on behalf of the PEARL study team   +6 more
doaj   +1 more source

Characterizing the metabolic phenotype of intestinal villus blunting in Zambian children with severe acute malnutrition and persistent diarrhea [PDF]

, 2018
Background: Environmental enteric dysfunction (EED) is widespread throughout the tropics and in children is associated with stunting and other adverse health outcomes. One of the hallmarks of EED is villus damage.
Amadi, B, Besa, E, Chandwe, K, Farras, M, Guerrant, R, Kelly, P, Louis-Auguste, J, Mayneris-Perxachs, J, Swann, J, Zyambo, K   +9 more
core   +12 more sources

An optimised protocol for detection of SARS-CoV-2 in stool

BMC Microbiology, 2021
Background SARS-CoV-2 has been detected in stool samples of COVID-19 patients, with potential implications for faecal-oral transmission. Compared to nasopharyngeal swab samples, the complexity of the stool matrix poses a challenge in the detection of the
Tianqi Li, Enriqueta Garcia-Gutierrez, Daniel A. Yara, Jacob Scadden, Jade Davies, Chloe Hutchins, Alp Aydin, Justin O’Grady, Arjan Narbad, Stefano Romano, Lizbeth Sayavedra   +10 more
doaj   +1 more source

Absence of Bacteria Permits Fungal Gut-To-Brain Translocation and Invasion in Germfree Mice but Ageing Alone Does Not Drive Pathobiont Expansion in Conventionally Raised Mice

Frontiers in Aging Neuroscience, 2022
Age-associated changes in the structure of the intestinal microbiome and in its interaction with the brain via the gut-brain axis are increasingly being implicated in neurological and neurodegenerative diseases.
Aimée Parker, Steve A. James, Catherine Purse, Arlaine Brion, Andrew Goldson, Andrea Telatin, David Baker, Simon R. Carding   +7 more
doaj   +1 more source

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Microbiome, 2022
Background Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias.
Aimée Parker, Stefano Romano, Rebecca Ansorge, Asmaa Aboelnour, Gwenaelle Le Gall, George M. Savva, Matthew G. Pontifex, Andrea Telatin, David Baker, Emily Jones, David Vauzour, Steven Rudder, L. Ashley Blackshaw, Glen Jeffery, Simon R. Carding   +14 more
doaj   +1 more source

Extracellular vesicles produced by the human gut commensal bacterium Bacteroides thetaiotaomicron elicit anti-inflammatory responses from innate immune cells

Frontiers in Microbiology, 2022
Bacterial extracellular vesicles (BEVs) produced by gut commensal bacteria have been proposed to play an important role in maintaining host homeostasis via interactions with the immune system.
Sonia Fonseca, Ana L. Carvalho, Ana L. Carvalho, Ariadna Miquel-Clopés, Emily J. Jones, Rokas Juodeikis, Régis Stentz, Simon R. Carding, Simon R. Carding   +8 more
doaj   +1 more source

LotuS2: an ultrafast and highly accurate tool for amplicon sequencing analysis

Microbiome, 2022
Background Amplicon sequencing is an established and cost-efficient method for profiling microbiomes. However, many available tools to process this data require both bioinformatics skills and high computational power to process big datasets. Furthermore,
Ezgi Özkurt, Joachim Fritscher, Nicola Soranzo, Duncan Y. K. Ng, Robert P. Davey, Mohammad Bahram, Falk Hildebrand   +6 more
doaj   +1 more source

Microbial lactate utilisation and the stability of the gut microbiome

Gut Microbiome, 2022
The human large intestinal microbiota thrives on dietary carbohydrates that are converted to a range of fermentation products. Short-chain fatty acids (acetate, propionate and butyrate) are the dominant fermentation acids that accumulate to high ...
Petra Louis, Sylvia Helen Duncan, Paul Owen Sheridan, Alan William Walker, Harry James Flint   +4 more
doaj   +1 more source

Higher total faecal short-chain fatty acid concentrations correlate with increasing proportions of butyrate and decreasing proportions of branched-chain fatty acids across multiple human studies

Gut Microbiome, 2022
Metabolites produced by microbial fermentation in the human intestine, especially short-chain fatty acids (SCFAs), are known to play important roles in colonic and systemic health.
Maria LaBouyer, Grietje Holtrop, Graham Horgan, Silvia W. Gratz, Alvaro Belenguer, Nicola Smith, Alan W. Walker, Sylvia H. Duncan, Alexandra M. Johnstone, Petra Louis, Harry J. Flint, Karen P. Scott   +11 more
doaj   +1 more source

Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice

Scientific Reports, 2023
Alterations in intestinal mucin glycosylation have been associated with increased intestinal permeability and sensitivity to inflammation and infection. Here, we used mice lacking core 3-derived O-glycans (C3GnT−/−) to investigate the effect of impaired ...
Erika Coletto, George M. Savva, Dimitrios Latousakis, Matthew Pontifex, Emmanuelle H. Crost, Laura Vaux, Andrea Telatin, Kirk Bergstrom, David Vauzour, Nathalie Juge   +9 more
doaj   +1 more source