Results 71 to 80 of about 8,960 (210)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Nature Communications
Early development of the gut ecosystem is crucial for lifelong health. While infant gut bacterial communities have been studied extensively, the infant gut virome remains under-explored. To study the development of the infant gut virome over time and the
Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, Lifelines NEXT cohort study, Jackie Dekens, Jan Sikkema, Folkert Kuipers, Andrey N. Shkoporov, Colin Hill, Sicco Scherjon, Cisca Wijmenga, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova   +20 more
doaj   +1 more source

Profiling of Human Gut Virome with Oxford Nanopore Technology

Medicine in Microecology, 2020
Human gut virome play critical roles in maintaining gut microbial composition and functionality, as well as host physiology and immunology. Yet, there are insufficient amount of studies on this topic mainly due to methodological limitations, including ...
Jiabao Cao, Yuqing Zhang, Min Dai, Jiayue Xu, Liang Chen, Faming Zhang, Na Zhao, Jun Wang   +7 more
doaj   +1 more source

Varidnaviruses in the Human Gut: A Major Expansion of the Order Vinavirales

Viruses, 2022
Bacteriophages play key roles in the dynamics of the human microbiome. By far the most abundant components of the human gut virome are tailed bacteriophages of the realm Duplodnaviria, in particular, crAss-like phages. However, apart from duplodnaviruses,
Natalya Yutin, Mike Rayko, Dmitry Antipov, Pascal Mutz, Yuri I. Wolf, Mart Krupovic, Eugene V. Koonin   +6 more
doaj   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Gut bacteriome, mycobiome and virome alterations in rheumatoid arthritis

Frontiers in Endocrinology, 2023
Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease of the joints which causes significant pain, functional disability, and mortality. Although aberrant immune cell activation induced by the imbalance between T helper Th1/Th17 and Treg cells is implicated in the RA development, its etiopathogenesis remains unclear.
Sonali Dagar, Jagdeep Singh, Aastha Saini, Yashwant Kumar, Seema Chhabra, Ranjana Walker Minz, Lekha Rani   +6 more
openaire   +3 more sources

Alterations of gut virome with close interaction in the progression of estrogen deficiency-induced osteoporosis

Gut Microbes
Previous research has established a link between gut microbiota and osteoporosis (OP) advancement. However, there remains a limited understanding of the crucial contribution of the gut virome in the onset and progression of OP.
Yueqi Chen, Chuan Yang, Zihan Deng, Tingwen Xiang, Jiulin Tan, Jianzhong Xu, Dong Sun, Fei Luo   +7 more
doaj   +1 more source

The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites

Virology Journal, 2019
Background The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance.
Heng Li, Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng, Zening Yang, Xing Huang, Manman Chu, Fengmei Yang, Zhanlong He, Nan Li, Jinxi Yang, Qiongwen Wu, Haijing Shi, Longding Liu   +15 more
doaj   +1 more source

Improving gut virome comparisons using predicted phage host information. [PDF]

mSystems
AbstractThe human gut virome is predominantly made up of bacteriophages (phages), viruses that infect bacteria. Metagenomic studies have revealed that phages in the gut are highly individual specific and dynamic. These features make it challenging to perform meaningful cross-study comparisons. While several taxonomy frameworks exist to group phages and
Shamash M, Sinha A, Maurice CF.
europepmc   +4 more sources