Results 11 to 20 of about 50,945 (202)

H3N2 Virus Outbreak: A latest global threat

Journal of Zoonotic Diseases, 2023
The current H3N2 virus outbreak has sent shockwaves worldwide, with health officials rushing to stop its spread. This form of influenza has been wreaking havoc around the globe, culminating in an alarming number of hospitalizations and fatalities.
Manisha Vohra , Mohammad Amir , Amit Sharma , Ian Osoro   +3 more
doaj   +2 more sources

Structure of an H3N2 influenza virus nucleoprotein [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2021
Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP.
Michael L. Knight, Haitian Fan, David L. V. Bauer, Jonathan M. Grimes, Ervin Fodor, Jeremy R. Keown   +5 more
openaire   +3 more sources

N-Linked Glycosylation Attenuates H3N2 Influenza Viruses [PDF]

Journal of Virology, 2007
ABSTRACT Over the last four decades, H3N2 subtype influenza A viruses have gradually acquired additional potential sites for glycosylation within the globular head of the hemagglutinin (HA) protein. Here, we have examined the biological effect of additional glycosylation on the virulence of H3N2 influenza viruses. We created otherwise
Vigerust, David J., Ulett, Kimberly B., Boyd, Kelli L., Madsen, Jens, Hawgood, Samuel, McCullers, Jonathan A.   +5 more
openaire   +3 more sources

Influenza A (H3N2) Outbreak, Nepal

Emerging Infectious Diseases, 2005
في يوليو 2004، تم اكتشاف تفشي الأنفلونزا A (H3N2) في 3 مخيمات للاجئين البوتانيين في جنوب شرق نيبال. أظهر تثبيط التراص الدموي أن ما يقرب من 40 ٪ من الفيروسات من هذا التفشي كانت متميزة مستضدًا عن سلالة لقاح A/Wyoming/3/03. لوحظت أربعة اختلافات في الأحماض الأمينية في معظم العزلات الـ 26 مقارنة باللقاح الأجنبي A/Wyoming/3/2003.
Luke T. Daum, Michael Shaw, Alexander Klimov, Linda C. Canas, Elizabeth Macias, Debra M. Niemeyer, James P. Chambers, Robert Renthal, Sanjaya K. Shrestha, Ramesh P. Acharya, Shankar P. Huzdar, Nirmal Rimal, Khin Saw Aye Myint, P. L. Gould   +13 more
openaire   +3 more sources

Isolation and Genetic Characterization of Emerging H3N2 Canine Influenza Virus in Guangdong Province, Southern China, 2018–2021

Frontiers in Veterinary Science, 2022
H3N2 canine influenza virus (CIV) emerged in dogs in China or Korea around 2005 and was first reported in 2008. In 2015, H3N2 CIV was detected in the United States and caused a huge outbreak.
Jiajun Ou, Jiajun Ou, Jiajun Ou, Feiyan Zheng, Feiyan Zheng, Feiyan Zheng, Jiaojiao Cheng, Jiaojiao Cheng, Jiaojiao Cheng, Shaotang S. Ye, Shaotang S. Ye, Shaotang S. Ye, Cundong Ye, Kun Jia, Kun Jia, Kun Jia, Gang Lu, Gang Lu, Gang Lu, Shoujun Li, Shoujun Li, Shoujun Li   +21 more
doaj   +1 more source

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]

, 2014
Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora, Clement, Frédéric, Del Giudice, Giuseppe, Della Cioppa, Giovanni, Galli, Grazia, Groth, Nicola, Leroux-Roels, Geert, Levin, Yotam, Lindert, Kelly, Nicolay, Uwe   +9 more
core   +1 more source

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1) pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE [PDF]

, 2015
The microneutralization assay is commonly used to detect antibodies to influenza virus, and multiple protocols are used worldwide. These protocols differ in the incubation time of the assay as well as in the order of specific steps, and even within ...
Engelhardt, OG, Heath, A, Hoschler, K, Hungnes, O, Katz, JM, Laurie, KL, Peiris, M, Van Kerkhove, MD, Wood, J, Zhang, W   +9 more
core   +1 more source

Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season

Vaccines, 2021
While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains.
Rakefet Pando, Shahar Stern, Ital Nemet, Aharona Glatman-Freedman, Hanna Sefty, Neta S. Zuckerman, Yaron Drori, Nehemya Friedman, John W. McCauley, Lital Keinan-Boker, Ella Mendelson, Rodney S. Daniels, Michal Mandelboim   +12 more
doaj   +1 more source

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009-2017 [PDF]

, 2020
Background Influenza viruses evolve rapidly and undergo immune driven selection, especially in the hemagglutinin (HA) protein. We report amino acid changes affecting antigenic epitopes and receptor‐binding sites of A(H3N2) viruses circulating in Kilifi,
Agoti, Charles N., Chaves, Sandra S., Ngoi, Joyce M., Nokes, D. James, Nyasimi, Festus M., Nyiro, Joyce U., Otieno, Grieven P., Otieno, James R., Owuor, D. Collins   +8 more
core   +1 more source