Results 41 to 50 of about 50,945 (202)
Viruses, 2022 Seasonal H3N2 influenza virus has always been a potential threat to public health. The reassortment of the human and avian H3N2 influenza viruses has resulted in major influenza outbreaks, which have seriously damaged human life and health. To assess the
Tengfei Liu +7 more
doaj +1 more source
Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]
, 2015 Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael +6 more
core +4 more sources
Mutational fitness landscape of human influenza H3N2 neuraminidase
Cell Reports, 2023 Influenza neuraminidase (NA) has received increasing attention as an effective vaccine target. However, its mutational tolerance is not well characterized. Here, the fitness effects of >6,000 mutations in human H3N2 NA are probed using deep mutational scanning.
Ruipeng Lei +9 more
openaire +4 more sources
npj Vaccines, 2022 History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied.
Nina Urke Ertesvåg +5 more
doaj +1 more source
Microbiology Spectrum, 2023 Due to antigenic drift and shift of influenza A viruses (IAV) and the tendency to elicit predominantly strain-specific antibodies, humanity remains susceptible to new strains of seasonal IAV and is at risk from viruses with pandemic potential for which ...
Michael Piepenbrink +10 more
doaj +1 more source
Genetic content of Influenza H3N2 vaccine seeds
PLoS Currents, 2010 Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds.
Bergeron, Corinne +3 more
openaire +4 more sources
Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]
, 2018 Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon +11 more
core +3 more sources
Evolution-informed forecasting of seasonal influenza A (H3N2) [PDF]
Science Translational Medicine, 2017 ABSTRACTInter-pandemic or seasonal influenza exacts an enormous annual burden both in terms of human health and economic impact. Incidence prediction ahead of season remains a challenge largely because of the virus’ antigenic evolution. We propose here a forecasting approach that incorporates evolutionary change into a mechanistic epidemiological model.
Du, Xiangjun +3 more
openaire +2 more sources
GAIMS Journal of Medical SciencesBackground: Influenza viruses cause significant respiratory illness, with seasonal epidemics and occasional pandemics influenced by antigenic variation. Monitoring local prevalence and subtype distribution is vital for guiding public health responses.
Gulshan Chaudhary +2 more
doaj +1 more source
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
core +1 more source