Results 71 to 80 of about 41,916 (253)

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding

PLoS Pathogens, 2020
In the 2014–2015 influenza season a novel neuraminidase (NA) genotype was detected in global human influenza A surveillance. This novel genotype encoded an N-linked glycosylation site at position 245–247 in the NA protein from clade 3c.2a H3N2 viruses ...
Harrison Powell, A. Pekosz
semanticscholar   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Ineffectiveness of the 2014-2015 H3N2 influenza vaccine

Oncotarget, 2015
The seasonal influenza vaccine is currently the most effective preventive modality against influenza infection. Nasopharyngeal samples of vaccinated and non-vaccinated patients presenting with Influenza-like-illness (ILI) were collected from over 20 outpatient clinics located in different geographic parts of Israel and were tested for the presence of ...
Michal, Mandelboim, Aharona, Glatman-Freedman, Yaron, Drori, Hilda, Sherbany, Rakefet, Pando, Hanna, Sefty, Hila, Zadka, Tamar, Shohat, Nathan, Keller, Ella, Mendelson   +9 more
openaire   +3 more sources

Comparative Analysis of Whole-Transcriptome RNA Expression in MDCK Cells Infected With the H3N2 and H5N1 Canine Influenza Viruses

Frontiers in Cellular and Infection Microbiology, 2019
This study aimed to detect changes in the complete transcriptome of MDCK cells after infection with the H5N1 and H3N2 canine influenza viruses using high-throughput sequencing, search for differentially expressed RNAs in the transcriptome of MDCK cells ...
Pan Tao, Pan Tao, Pan Tao, Zhangyong Ning, Xiangqi Hao, Xiangqi Hao, Xiangqi Hao, Xi Lin, Xi Lin, Xi Lin, Qingxu Zheng, Qingxu Zheng, Qingxu Zheng, Shoujun Li, Shoujun Li, Shoujun Li   +15 more
doaj   +1 more source

The Hong Kong Influenza Virus: Treats to the Portrait after 50 Years and the Future Influenza Pandemic

Эпидемиология и вакцинопрофилактика, 2020
Relevance. Of the different subtypes, H3N2 influenza virus subtype has the highest variability and pathogenicity, often dominates in epidemiological seasons and induces high mortality exceeding its rate in pandemic.
E. P. Kharchenko
doaj   +1 more source

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Frontiers in Immunology, 2020
Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy ...
Shannon M Miller, V. Cybulski, Margaret N. Whitacre, L. Bess, M. Livesay, L. Walsh, D. Burkhart, H. Bazin, Jay T. Evans   +8 more
semanticscholar   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Explaining the geographical origins of seasonal influenza A (H3N2) [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2016
Most antigenically novel and evolutionarily successful strains of seasonal influenza A (H3N2) originate in East, South and Southeast Asia. To understand this pattern, we simulated the ecological and evolutionary dynamics of influenza in a host metapopulation representing the temperate north, tropics and temperate south.
Frank Wen, Trevor Bedford, Sarah Cobey
openaire   +3 more sources

Characteristics of influenza virus epidemic in Yiwu City, Zhejiang Province from 2017 to 2022

Shanghai yufang yixue
ObjectiveTo investigate the epidemiological trends of influenza in Yiwu City, Zhejiang Province from 2017 to 2022, and to provide references for local adjustments to influenza prevention and control strategies.MethodsReal-time fluorescence quantitative ...
CHEN Buqing, CHEN Bo, LOU Junfang, CHEN Jinhua   +3 more
doaj   +1 more source