Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model [PDF]
Frontiers in Immunology, 2017 Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global threat. The only approved vaccine against TB, Mycobacterium bovis bacillus Calmette–Guérin (BCG), provides insufficient protection and, being a live vaccine, can cause ...
Anouk C. M. Platteel +8 more
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Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]
, 2014 BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Andersen, Peter +20 more
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Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes [PDF]
Frontiers in Microbiology, 2018 Tuberculosis (TB) is the leading cause of death by an infectious agent, and developing an effective vaccine is an important component of the WHO's EndTB Strategy.
Louis R. Joslyn +10 more
doaj +3 more sources
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients [PDF]
Nature Communications, 2021 Modulating the host immune response during tuberculosis is an emerging and critical advance in the therapeutic approach. Here the authors present data from a first-in-human phase I/II randomised trial on the safety and immunogenicity of adjuvant therapy ...
Synne Jenum +13 more
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Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization [PDF]
Frontiers in Immunology, 2018 Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Aneesh Thakur +10 more
doaj +5 more sources
Toll like-receptor agonist Pam3Cys modulates the immunogenicity of liposomes containing the tuberculosis vaccine candidate H56 [PDF]
Medical Microbiology and Immunology, 2020 AbstractA major roadblock in the development of novel vaccines is the formulation and delivery of the antigen. Liposomes composed of a dimethyldioctadecylammonium (DDA) backbone and the adjuvant trehalose-6-6-dibehenate (TDB, termed “cationic adjuvant formulation (CAF01)”, promote immunogenicity and protective efficacy of vaccines, most notably against
Kennerknecht, Kathrin +8 more
openaire +3 more sources
Myocardial and haemodynamic effects of the beta‐adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats [PDF]
British Journal of Pharmacology, 1969 . The effects of the beta‐adrenoceptor blocking drug alprenolol (H56/28) on myocardial and general haemodynamics were studied in anaesthetized cats.. Alprenolol (0·5 mg/kg and 1·0 mg/kg) reduced femoral systolic and diastolic pressures, heart rate and left ventricular systolic pressure.
J. R. PARRATT, R. M. WADSWORTH
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BMN Operators for N=1 Superconformal Yang-Mills Theories and Associated String Backgrounds [PDF]
, 2002 We study a class of near-BPS operators for a complex 2-parameter family of N=1 superconformal Yang-Mills theories that can be obtained by a Leigh-Strassler deformation of N=4 SYM theory. We identify these operators in the large N and large R-charge limit
A. Ceresole +42 more
core +5 more sources
Frontiers in Immunology, 2018 The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting.
Annalisa Ciabattini +10 more
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Sextonians and the magic square [PDF]
, 2004 Associated to any complex simple Lie algebra is a non-reductive complex Lie algebra which we call the intermediate Lie algebra. We propose that these algebras can be included in both the magic square and the magic triangle to give an additional row and ...
Westbury, Bruce
core +3 more sources