Results 31 to 40 of about 15,676 (196)

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

Frontiers in Cell and Developmental Biology, 2020
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in
Prathamesh T. Nadar-Ponniah, Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld   +14 more
doaj   +1 more source

Protective effect of astaxanthin nanoemulsion on mammalian inner ear hair cells [PDF]

PeerJ, 2023
Background Aminoglycoside antibiotics are used for treating certain acute infections. However, these drugs cause ototoxicity by inducing inner ear hair cell death.
Yuki Kobayashi, Kazuma Sugahara, Yosuke Takemoto, Junko Tsuda, Yoshinobu Hirose, Makoto Hashimoto, Hiroshi Yamashita   +6 more
doaj   +2 more sources

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

eLife, 2015
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network
Vincent, Philippe F. Y., Bouleau, Yohan, Petit, Christine, Dulon, Didier   +3 more
openaire   +4 more sources

A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs

Frontiers in Neuroscience, 2021
Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini, Basile Tarchini, Basile Tarchini   +2 more
doaj   +1 more source

Differences in auditory nerve fiber responses in regard to inner and outer hair cells [PDF]

The Journal of the Acoustical Society of America, 1978
Single unit recordings were made from auditory nerve fibers in the monkey to pure tone stimuli. Extensive studies of frequency response areas suggested the existence of two types of auditory nerve fibers. One type showed a flat-bottomed response area and the other showed a conventional sharp one.
M. Nomoto, M. Maekawa
openaire   +1 more source

Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1 [PDF]

eneuro, 2016
AbstractAuditory neuropathy 1 (AUNA1) is a form of human deafness resulting from a point mutation in the 5′ untranslated region of theDiaphanous homolog 3(DIAPH3) gene. Notably, theDIAPH3mutation leads to the overexpression of the DIAPH3 protein, a formin family member involved in cytoskeleton dynamics. Through study of diap3-overexpressing transgenic (
Surel, Clément, Guillet, Marie, Lenoir, Marc, Bourien, Jérôme, Sendin, Gaston, Joly, Willy, Delprat, Benjamin, Lesperance, Marci, Puel, Jean-Luc, Nouvian, Regis   +9 more
openaire   +3 more sources

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +1 more source

Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]

Cellular and Molecular Life Sciences, 2009
It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones. The receptors for Epo and VEGF are widely expressed in different organs.
Monge Naldi, Arianne, Gassmann, Max, Bodmer, Daniel   +2 more
openaire   +4 more sources

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus, Jean-Charles Ceccato, Gaston Sendin, Jérôme Bourien, Jean-Luc Puel, Régis Nouvian   +5 more
doaj   +1 more source

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti   +12 more
doaj   +1 more source