Results 41 to 50 of about 15,322 (225)

Age-related changes in auditory nerve–inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice [PDF]

Neuroscience, 2015
This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in gap detection (GD), the latter as an indicator of auditory temporal processing.
Catherine L. Martin, Richard A. Altschuler, Karin Halsey, Jochen Schacht, N. Deng, David F. Dolan, David C. Kohrman, Ariane Kanicki, J. Eberle, Richard A. Miller   +9 more
openaire   +3 more sources

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Neural Plasticity, 2018
Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced ...
Muhammad Waqas, Song Gao, Iram-us-Salam, Muhammad Kazim Ali, Yongming Ma, Wenyan Li   +5 more
doaj   +1 more source

Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice

Frontiers in Cellular Neuroscience, 2021
Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo.
Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Longhao Wang, Longhao Wang, Longhao Wang, Hu Peng, Huihui Liu, Huihui Liu, Huihui Liu, Hongchao Liu, Hongchao Liu, Hongchao Liu, Qingyue Yuan, Qingyue Yuan, Qingyue Yuan, Yun Lin, Yun Lin, Yun Lin, Jun Xu, Jun Xu, Jun Xu, Xiuhong Pang, Hao Wu, Hao Wu, Hao Wu, Tao Yang, Tao Yang, Tao Yang   +28 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Neural Regeneration Research, 2023
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen   +9 more
doaj   +1 more source

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

eLife, 2015
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network
Christine Petit, Philippe F.Y. Vincent, Didier Dulon, Didier Dulon, Yohan Bouleau   +4 more
openaire   +5 more sources

Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications

Advanced Materials, EarlyView.
Biological and biologically‐inspired functional nanostructures with structural, thermal, optical, and sensing applications are reviewed. The role of nanoscale features in biological materials on performance is described, and their blueprints are used for bio‐inspired nanomaterials, synthesized using advanced techniques (i.e., photolithography, bio ...
Chao Hsuan (Joseph) Sung, Taige Hao, Herry Fang, Andrew Tran Nguyen, Valentina Perricone, Haitao Yu, Wei Huang, Ezra Sarmiento, Adrian Francisco Duran Ornelas, Derek Lublin, Ric Wehling, Sanaz Farajollahi, Atsushi Arakaki, Dhriti Nepal, Nathan Patrick Lord, David Kisailus   +15 more
wiley   +1 more source

Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability [PDF]

Developmental Dynamics, 2013
Background: Hearing restoration through hair cell regeneration will require revealing the dynamic interactions between proliferation and differentiation during development to avoid the limited viability of regenerated hair cells. Pax2‐Cre N‐Myc conditional knockout (CKO) mice highlighted the need of N‐Myc for proper neurosensory development and ...
Israt Jahan, Bernd Fritzsch, Benjamin Kopecky, Benjamin Kopecky   +3 more
openaire   +2 more sources

Autonomous Implants

Advanced Materials, EarlyView.
An ideal implant should mimic native tissues such that it can integrate, sense, heal, and continue to function, i.e., be autonomous. Although early, there are good steps taken in this way, e.g., the development of stimuli‐responsive, self‐powering, self‐actuating, self‐healing, self‐regenerating, and self‐aware implants.
Jagan Mohan Dodda, Marcel F. Kunrath, Ling Zhou Zhao, Mahdi Bodaghi, Armin Yousefi, Nureddin Ashammakhi   +5 more
wiley   +1 more source

Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells

Molecular & Cellular Proteomics
In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory information to the brain. The presynaptic machinery responsible for neurotransmitter release in IHC synapses includes proteins such as the multi-C2-domain protein otoferlin and the vesicular glutamate transporter 3 (VGluT3).
Andreia P. Cepeda, Momchil Ninov, Jakob Neef, Iwan Parfentev, Kathrin Kusch, Ellen Reisinger, Reinhard Jahn, Tobias Moser, Henning Urlaub   +8 more
openaire   +4 more sources