Results 61 to 70 of about 50,821 (291)
Evaluation of inner hair cell and nerve fiber loss as sufficient pathologies underlying auditory neuropathy [PDF]
Hearing Research, 2009 Auditory neuropathy is a hearing disorder characterized by normal function of outer hair cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions (OAEs), with absent or severely dys-synchronized auditory brainstem responses (ABRs).
Sandra L. McFadden, Mohamed M. El-Badry
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2020 Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson +5 more
doaj +1 more source
Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
core +1 more source
Frontiers in Molecular Neuroscience, 2018 Before the onset of hearing, which occurs around postnatal day 12 (P12) in mice, inner hair cells (IHCs) of the immature cochlea generate sound-independent Ca2+ action potentials (APs), which stimulate the auditory pathway and guide maturation of ...
T. Eckrich +3 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2018 During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus +5 more
doaj +1 more source
Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]
, 2015 This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
core +3 more sources
RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells
Scientific Data, 2018 Although hair cells are the sensory receptors of the auditory and vestibular systems in the ears of all vertebrates, hair cell properties are different between non-mammalian vertebrates and mammals.
C. Barta +7 more
semanticscholar +1 more source
Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Synaptic transmission is codetermined by presynaptic and postsynaptic neurons. Therefore, to understand how the inner hair cell (IHC) signals to spiral ganglion neurons at the first synapse in the auditory pathway, here we directly studied ...
C. Grabner, T. Moser
semanticscholar +1 more source
Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage
Neural Plasticity, 2018 Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced ...
Muhammad Waqas +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo.
Pengcheng Xu +28 more
doaj +1 more source