Results 61 to 70 of about 37,698 (205)

Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells

Molecular & Cellular Proteomics
In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory information to the brain. The presynaptic machinery responsible for neurotransmitter release in IHC synapses includes proteins such as the multi-C2-domain protein otoferlin and the vesicular glutamate transporter 3 (VGluT3).
Andreia P. Cepeda, Momchil Ninov, Jakob Neef, Iwan Parfentev, Kathrin Kusch, Ellen Reisinger, Reinhard Jahn, Tobias Moser, Henning Urlaub   +8 more
openaire   +4 more sources

PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Neural Regeneration Research, 2023
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen   +9 more
doaj   +1 more source

Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]

, 2017
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
core   +1 more source

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +1 more source

Live Demonstration: Real-time neuro-inspired sound source localization and tracking architecture applied to a robotic platform [PDF]

, 2018
This live demonstration presents a sound source localization and tracking system implemented with Spike Signal Processing (SSP) building blocks on FPGA devices.
Cerezuela Escudero, Elena, Jiménez Fernández, Ángel Francisco, Morgado Estévez, Arturo, Pérez Peña, Fernando   +3 more
core  

Tone-in-noise detection deficits in elderly patients with clinically normal hearing [PDF]

, 2019
One of the most common complaints among the elderly is the inability to understand speech in noisy environments. In many cases, these deficits are due to age-related hearing loss; however, some of the elderly that have difficulty hearing in noise have ...
Cappelli, Giampietro, De Vincentiis, Marco, Greco, Antonio, Neri, Ilaria, Ralli, Massimo, Salvi, Richard, Sheppard, Adam   +6 more
core   +1 more source

A Biophysical Model of the Inner Hair Cell: The Contribution of Potassium Currents to Peripheral Auditory Compression [PDF]

Journal of the Association for Research in Otolaryngology, 2006
The term peripheral auditory compression refers to the fact that the whole range of audible sound pressure levels is mapped into a narrower range of auditory nerve responses. Peripheral compression is the by-product of independent compressive processes occurring at the level of the basilar membrane, the inner hair cell (IHC), and the auditory nerve ...
Enrique A, Lopez-Poveda, Almudena, Eustaquio-Martín   +1 more
openaire   +2 more sources

Insights into the regulation of hearing regeneration

Frontiers in Audiology and Otology
Our perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
doaj   +1 more source

Systemic lupus erythematosus and hearing disorders: literature review and meta-analysis of clinical and temporal bone findings [PDF]

, 2017
Objective: This literature review and meta-analysis was performed to evaluate the correlations among hearing and vestibular clinical symptoms, temporal bone findings, and pathological mechanisms in patients with systemic lupus erythematosus (SLE).
DI STADIO, Arianna, Ralli, Massimo
core   +1 more source

Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]

, 2017
In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A., He, X.J., Kindt, K.S., Marcotti, W., Nicolson, T., Olt, J., Petralia, R.S., Schreck, M., Sheets, L., Trapani, J.G., Wang, Y-X., Zhang, Q.   +11 more
core   +1 more source