Results 61 to 70 of about 50,414 (231)

Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice

The FASEB Journal, 2019
The channel that governs mechanotransduction (MT) by hair cells in the inner ear has been investigated intensively for 4 decades, but its precise molecular composition remains enigmatic. Transmembrane channel‐like protein 1 (TMC1) was recently identified
Xiaofen Li, Xiaojie Yu, Xibing Chen, Zhengzhao Liu, Guangqin Wang, Chao Li, E. Wong, M. Sham, Jie Tang, Jufang He, Wei Xiong, Zhiyong Liu, Pingbo Huang   +12 more
semanticscholar   +1 more source

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus, Jean-Charles Ceccato, Gaston Sendin, Jérôme Bourien, Jean-Luc Puel, Régis Nouvian   +5 more
doaj   +1 more source

Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea

Frontiers in Molecular Neuroscience, 2018
Before the onset of hearing, which occurs around postnatal day 12 (P12) in mice, inner hair cells (IHCs) of the immature cochlea generate sound-independent Ca2+ action potentials (APs), which stimulate the auditory pathway and guide maturation of ...
T. Eckrich, Kerstin Blum, I. Milenkovic, J. Engel   +3 more
semanticscholar   +1 more source

Evaluation of inner hair cell and nerve fiber loss as sufficient pathologies underlying auditory neuropathy [PDF]

Hearing Research, 2009
Auditory neuropathy is a hearing disorder characterized by normal function of outer hair cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions (OAEs), with absent or severely dys-synchronized auditory brainstem responses (ABRs).
Sandra L. McFadden, Mohamed M. El-Badry
openaire   +3 more sources

Cochlear Model for Hearing Loss [PDF]

, 2015
In many psychoacoustical tasks, hearing-impaired subjects display abnormal audiograms and poor understanding of speech compared to normal listeners. Existing models that explain the performance of the hearing impaired indicate that possible sources for ...
Furst, Miriam
core   +1 more source

RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells

Scientific Data, 2018
Although hair cells are the sensory receptors of the auditory and vestibular systems in the ears of all vertebrates, hair cell properties are different between non-mammalian vertebrates and mammals.
C. Barta, Huizhan Liu, Lei Chen, Kimberlee P. Giffen, Yi Li, K. L. Kramer, K. Beisel, D. He   +7 more
semanticscholar   +1 more source

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Neural Plasticity, 2018
Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced ...
Muhammad Waqas, Song Gao, Iram-us-Salam, Muhammad Kazim Ali, Yongming Ma, Wenyan Li   +5 more
doaj   +1 more source

Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice

Frontiers in Cellular Neuroscience, 2021
Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo.
Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Longhao Wang, Longhao Wang, Longhao Wang, Hu Peng, Huihui Liu, Huihui Liu, Huihui Liu, Hongchao Liu, Hongchao Liu, Hongchao Liu, Qingyue Yuan, Qingyue Yuan, Qingyue Yuan, Yun Lin, Yun Lin, Yun Lin, Jun Xu, Jun Xu, Jun Xu, Xiuhong Pang, Hao Wu, Hao Wu, Hao Wu, Tao Yang, Tao Yang, Tao Yang   +28 more
doaj   +1 more source

Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system [PDF]

, 2007
A dominant mutation of the gene encoding the POU4F3 transcription factor underlies human non-syndromic progressive hearing loss DFNA15. Using oligonucleotide microarrays to generate expression profiles of inner ears of Pou4f3 ddl/ ddl mutant and wild ...
Ahmed, Zubair M., Avraham, Karen B., Camper, Sally A., Dror, Amiel A., Ellsworth, Buffy, Friedman, Thomas B., Hertzano, Ronna, Kelley, Matthew W., Montcouquiol, Mireille   +8 more
core   +1 more source

Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Synaptic transmission is codetermined by presynaptic and postsynaptic neurons. Therefore, to understand how the inner hair cell (IHC) signals to spiral ganglion neurons at the first synapse in the auditory pathway, here we directly studied ...
C. Grabner, T. Moser
semanticscholar   +1 more source