Results 71 to 80 of about 50,414 (231)

Age-related changes in auditory nerve–inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice [PDF]

Neuroscience, 2015
This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in gap detection (GD), the latter as an indicator of auditory temporal processing.
Catherine L. Martin, Richard A. Altschuler, Karin Halsey, Jochen Schacht, N. Deng, David F. Dolan, David C. Kohrman, Ariane Kanicki, J. Eberle, Richard A. Miller   +9 more
openaire   +3 more sources

PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Neural Regeneration Research, 2023
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen   +9 more
doaj   +1 more source

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Nature Communications, 2017
Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact ...
A. Giese, Yiquan Tang, G. P. Sinha, M. Bowl, Adam C Goldring, A. Parker, Mary J. Freeman, Steve D. M. Brown, S. Riazuddin, R. Fettiplace, W. Schafer, G. Frolenkov, Zubair M. Ahmed   +12 more
semanticscholar   +1 more source

Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices

Stem Cells International, 2019
Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; yet to date, there are few studies describing the use of human pluripotent stem cells (hPSCs) for this purpose.
Tomoko Hyakumura, S. McDougall, S. Finch, K. Needham, M. Dottori, B. Nayagam   +5 more
semanticscholar   +1 more source

Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]

, 2017
In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A., He, X.J., Kindt, K.S., Marcotti, W., Nicolson, T., Olt, J., Petralia, R.S., Schreck, M., Sheets, L., Trapani, J.G., Wang, Y-X., Zhang, Q.   +11 more
core   +1 more source

Tinnitus development is associated with synaptopathy of inner hair cells in Mongolian gerbils

bioRxiv, 2018
Human hearing loss (HL) is often accompanied by comorbidities like tinnitus which is affecting up to 15% of the adult population. Rodent animal studies could show that tinnitus may not only be a result of apparent HL due to cochlear hair cell damage but ...
Konstantin Tziridis, J. Forster, Isabelle Buchheidt-Dörfler, P. Krauss, A. Schilling, O. Wendler, Elisabeth Sterna, H. Schulze   +7 more
semanticscholar   +1 more source

Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability [PDF]

Developmental Dynamics, 2013
Background: Hearing restoration through hair cell regeneration will require revealing the dynamic interactions between proliferation and differentiation during development to avoid the limited viability of regenerated hair cells. Pax2‐Cre N‐Myc conditional knockout (CKO) mice highlighted the need of N‐Myc for proper neurosensory development and ...
Israt Jahan, Bernd Fritzsch, Benjamin Kopecky, Benjamin Kopecky   +3 more
openaire   +2 more sources

Insights into the regulation of hearing regeneration

Frontiers in Audiology and Otology
Our perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
doaj   +1 more source

Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells

Molecular & Cellular Proteomics
In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory information to the brain. The presynaptic machinery responsible for neurotransmitter release in IHC synapses includes proteins such as the multi-C2-domain protein otoferlin and the vesicular glutamate transporter 3 (VGluT3).
Andreia P. Cepeda, Momchil Ninov, Jakob Neef, Iwan Parfentev, Kathrin Kusch, Ellen Reisinger, Reinhard Jahn, Tobias Moser, Henning Urlaub   +8 more
openaire   +4 more sources

Potential of Gene and Cell Therapy for Inner Ear Hair Cells

BioMed Research International, 2018
Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing ...
Min Yong Lee, Yong-Ho Park
semanticscholar   +1 more source