Results 81 to 90 of about 50,414 (231)
A novel ENU-induced mutation in Myo6 causes vestibular dysfunction and deafness [PDF]
, 2016 Mouse N-ethyl-N-nitrosourea (ENU) mutagenesis has generated many useful animal models for human diseases. Here we describe the identification of a novel ENU-induced mouse mutant strain Turner (Tur) that displays circling and headtossing behavior and ...
Brahmachary, M +3 more
core +1 more source
Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea [PDF]
, 2020 Sound amplification within the mammalian cochlea depends upon specialized hair cells, the outer hair cells (OHCs), which possess both sensory and motile capabilities.
Ceriani, Federico +7 more
core +2 more sources
Scientific Reports, 2018 Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear.
Y. Asai +11 more
semanticscholar +1 more source
Nature Communications, 2022 Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use deep, single cell transcriptomics to study the molecular mechanisms that
C. Petitpré +8 more
semanticscholar +1 more source
Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
Scientific Reports, 2017 The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback.
Nikola Ciganović +2 more
doaj +1 more source
Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea. [PDF]
PLoS ONE, 2016 CaBPs are a family of EF-hand Ca2+ binding proteins that are structurally similar to calmodulin. CaBPs can interact with, and yet differentially modulate, effectors that are regulated by calmodulin, such as Cav1 voltage-gated Ca2+ channels ...
Tian Yang +5 more
doaj +1 more source
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
eLife, 2017 Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of
A. C. Vélez-Ortega +4 more
semanticscholar +1 more source
Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain [PDF]
Neurobiology of Aging, 2016 A dramatic shift in societal demographics will lead to rapid growth in the number of older people with hearing deficits. Poorer performance in suprathreshold speech understanding and temporal processing with age has been previously linked with progressing inner hair cell (IHC) synaptopathy that precedes age-dependent elevation of auditory thresholds ...
Dan Bing +7 more
openaire +4 more sources
Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons [PDF]
, 2015 During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same ...
Hume, Clifford +8 more
core +2 more sources