Results 101 to 110 of about 119,470 (327)

Proliferative generation of mammalian auditory hair cells in culture

Mechanisms of Development, 2002
Hair cell (HC) and supporting cell (SC) productions are completed during early embryonic development of the mammalian cochlea. This study shows that acutely dissociated cells from the newborn rat organ of Corti, developed into so-called otospheres consisting of 98% nestin (+) cells when plated on a non-adherent substratum in the presence of either ...
Laurent Nguyen, Bernard Rogister, Shibeshih Belachew, Philippe Lefèbvre, Philippe Lefèbvre, Marc Thiry, Gustave Moonen, Maria Luz Alvarez, Thomas R. Van De Water, Thomas R. Van De Water, Brigitte Malgrange, Jean-Michel Rigo   +11 more
openaire   +3 more sources

Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]

, 2013
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G., Avallone, B., Di Bonito, M., Franze, A. M., Mancuso, M., Narita, Y., Puelles, L., Rijli, F. M., Sequino, L., Studer, M.   +9 more
core   +5 more sources

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

Frontiers in Cellular Neuroscience, 2018
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus, Jean-Charles Ceccato, Gaston Sendin, Jérôme Bourien, Jean-Luc Puel, Régis Nouvian   +5 more
doaj   +1 more source

Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. [PDF]

PLoS ONE, 2010
Auditory hair cells spontaneously regenerate following injury in birds but not mammals. A better understanding of the molecular events underlying hair cell regeneration in birds may allow for identification and eventually manipulation of relevant ...
Corey S Frucht, Mohamed Uduman, Jamie L Duke, Steven H Kleinstein, Joseph Santos-Sacchi, Dhasakumar S Navaratnam   +5 more
doaj   +1 more source

Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium
V. Zampini, L. Rüttiger, Stuart L. Johnson, Christoph Franz, D. Furness, Jörg Waldhaus, Hao Xiong, C. Hackney, M. Holley, Nina Offenhauser, P. P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
semanticscholar   +1 more source

A ratchet mechanism for amplification in low-frequency mammalian hearing

, 2010
The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells. In most vertebrates the active process stems from the active motility of hair bundles.
A. J. Hudspeth, Ashmore, Chan, Cooper, Cooper, Dallos, Dong, Evans, Gummer, Housley, Kennedy, Khanna, Kiang, Mammano, Martin, Mellado Lagarde, Naidu, Nuttall, Robles, Ruggero, Santos-Sacchi, Sziklai, T. Reichenbach, Ulfendahl, Zheng, Zinn, Zwislocki   +26 more
core   +2 more sources

Intraoperative electrocochleographic characteristics of auditory neuropathy spectrum disorder in cochlear implant subjects [PDF]

, 2017
Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing.
Adunka, Oliver F, Bastian, Zachary J, Brown, Kevin D, Buchman, Craig A, Fitzpatrick, Douglas C, Fontenot, Tatyana E, Giardina, Christopher K, Harris, Michael S, Riggs, William J, Roche, Joseph P   +9 more
core   +4 more sources

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

It takes two

eLife, 2015
Two forms of an unconventional myosin motor protein have separate functions in the growth and maintenance of hair bundles in auditory hair cells.
Teresa Nicolson
doaj   +1 more source