Results 141 to 150 of about 119,470 (327)

Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His

IBRO Neuroscience Reports, 2022
Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the development of the hindbrain choroid plexus, and of the rhombic lips in the development of hindbrain auditory centers.
Joel C. Glover, Bernd Fritzsch
doaj  

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

eLife, 2017
Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestibular
T. Erickson, C. Morgan, J. Olt, K. Hardy, E. Busch-Nentwich, Reo Maeda, Rachel Clemens, Jocelyn F Krey, Alex V. Nechiporuk, Peter G. Barr-Gillespie, W. Marcotti, T. Nicolson   +11 more
semanticscholar   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Cells, 2019
Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular ...
Kun Hou, Hui Jiang, Md. Rezaul Karim, Chao Zhong, Zhouwen Xu, Lin Liu, Minxin Guan, Jianzhong Shao, Xiao Huang   +8 more
doaj   +1 more source

Temporal–Spatial Replication of the Pulse Haptic Sensation Empowered by Multifunctional Piezoelectret

Advanced Intelligent Systems, EarlyView.
Dynamic pressure sensing, static pressure sensing, and haptic vibration are implemented on multifunctional piezoelectret devices with the universal structural design, further combined with the customized pressure device to comprehensively simulate and expand the Traditional Chinese Medicine (TCM) three‐finger palpation.
Liuyang Han, Wei Zeng, Nianping Zhang, Dong Cao, Wenting Chen, Qiliang Chen, Qisen Xie, Ziyao Qi, Ying Dong, Xiaohao Wang   +9 more
wiley   +1 more source

Regeneration and Mammalian Auditory Hair Cells [PDF]

Science, 1995
S Chardin, R Romand
openaire   +3 more sources

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15

Journal of Neuroscience, 2010
Tip links are extracellular filaments that connect pairs of hair cell stereocilia and convey tension to mechanosensitive channels. Recent evidence suggests that tip links are formed by calcium-dependent interactions between the N-terminal domains of ...
A. Lelli, Piotr Kaźmierczak, Yoshiyuki Kawashima, U. Müller, J. R. Holt   +4 more
semanticscholar   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses

Neural Plasticity, 2017
The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology ...
Changquan Wang, Zhenmin Zhong, Peng Sun, Hanbing Zhong, Hongzhe Li, Fangyi Chen   +5 more
doaj   +1 more source

Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment

Journal of the Association for Research in Otolaryngology, 2017
The absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the
Abhilash Ponnath, Frederic F S Depreux, Francine M. Jodelka, F. Rigo, H. Farris, M. Hastings, J. Lentz   +6 more
semanticscholar   +1 more source