Results 151 to 160 of about 119,470 (327)

The Behavioral Phenotype and Importance of Multidisciplinary Care in Patients With Sotos Syndrome: A Single‐Center Experience

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Sotos syndrome is an autosomal dominant condition caused by pathogenic variants in the NSD1 gene on chromosome 5q35. It is characterized by macrosomia, distinctive facial features, and developmental delays. Patients are also reported to have a behavioral phenotype including autism spectrum disorder, attention deficit/hyperactivity disorder ...
Aravind Viswanathan, Andrew M. George, Evan R. Hathaway, Carlyn Glatts, Jennifer M. Kalish   +4 more
wiley   +1 more source

Early synapsids neurosensory diversity revealed by CT and synchrotron scanning

The Anatomical Record, EarlyView.
Abstract Non‐mammaliaform synapsids (NMS) represent the closest relatives of today's mammals among the early amniotes. Exploring their brain and nervous system is key to understanding how mammals evolved. Here, using CT and Synchrotron scanning, we document for the first time three extreme cases of neurosensory and behavioral adaptations that probe ...
J. Benoit, R. Araujo, E. S. Lund, A. Bolton, T. Lafferty, Z. Macungo, V. Fernandez   +6 more
wiley   +1 more source

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Scientific Reports, 2018
Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear.
Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc   +11 more
doaj   +1 more source

Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results

Brazilian Journal of Medical and Biological Research, 2016
In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the ...
L.C.M. Barboza Jr., K. Lezirovitz, D.B. Zanatta, B.E. Strauss, R.C. Mingroni-Netto, J. Oiticica, L.A. Haddad, R.F. Bento   +7 more
doaj   +1 more source

Technological Innovations and Applications of Spatial Transcriptomics in Livestock and Poultry Research

Animal Research and One Health, EarlyView.
The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang, Ao Guo, Lin Zhang, Shengru Wu, Juan Du, Taiyong Yu   +5 more
wiley   +1 more source

Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea

Journal of Otology, 2020
Objective: To investigate the role of the periotic mesenchyme (POM) in the development of sensory cells of developing auditory epithelium. Methods: Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic ...
Jingjiang Huang, Na Zuo, Cheng Wu, Peipei Chen, Jun Ma, Chuanxi Wang, Wenyan Li, Shaofeng Liu   +7 more
doaj  

Tuning and Amplification in Gecko Auditory Hair Cells

We developed an isolated auditory papilla of the crested gecko to record from the hair cells and explore the origins of frequency tuning. Low-frequency cells displayed electrical tuning, dependent on Ca2+-activated K+ channels; high-frequency cells, overlain with sallets, showed a variation in hair bundle stiffness which when combined with sallet mass ...
Fettiplace, Robert, Beurg, Maryline
openaire   +3 more sources

Neural electrodes for brain‐computer interface system: From rigid to soft

BMEMat, EarlyView.
Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang, Gongwei Tian, Jianhui Chen, Yan Liu, Esha Fatima, Jichuan Qiu, Nik Ahmad Nizam Nik Malek, Dianpeng Qi   +7 more
wiley   +1 more source

Protective Effects of Buckwheat and Isoquercitrin Against Noise‐Induced Hearing Loss in Mice: An Antioxidant Strategy Targeting the Nrf2/HO‐1 Pathway in Auditory Hair Cells

Food Frontiers, EarlyView.
Isoquercitrin (IQ), a major bioactive compound in buckwheat (Fagopyrum esculentum Moench; BW), serves as a key mediator of the protective effects of BW against noise‐induced hearing loss (NIHL) by activating the Nrf2/HO‐1 signaling pathway, and oral administration of BW and IQ significantly attenuates oxidative stress and hair cell apoptosis through ...
Hojin Lee, Gahwa Jung, Guijae Yoo, Jonghoon Jung, Jae‐Yong Park, Changho Lee, Jaekwang Lee   +6 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source