Results 11 to 20 of about 22,677 (167)
Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Mechanisms of Active Hair Bundle Motion in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2002 Sound stimuli vibrate the hair bundles on auditory hair cells, but the resulting motion attributable to the mechanical stimulus may be modified by forces intrinsic to the bundle, which drive it actively. One category of active hair bundle motion has properties similar to fast adaptation of the mechanotransducer channels and is explicable if gating of ...
A J, Ricci, A C, Crawford, R, Fettiplace
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A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
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Resveratrol Protects Auditory Hair Cells from Gentamicin Toxicity [PDF]
Ear, Nose & Throat Journal, 2008 Resveratrol is a naturally occurring polyphenol that is synthesized by a variety of plant species. It is abundant in grapes and grape products (e.g., red wine). Resveratrol has demonstrated reactive oxygen species (ROS) scavenger activity, and it has been linked to nuclear factor-kappa B (NF-κB) activity.
Bonabi, Sharouz +4 more
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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mTORC2 regulates auditory hair cell structure and function
iScience, 2023 mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice. HC-RicKO mice exhibited early-onset, progressive, and profound hearing loss.
Maurizio Cortada +3 more
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Active hair bundle movements in auditory hair cells [PDF]
The Journal of Physiology, 2006 The frequency selectivity of mammalian hearing depends on not only the passive mechanics of the basilar membrane but also an active amplification of the mechanical stimulus by the cochlear hair cells. The common view is that amplification stems from the somatic motility of the outer hair cells (OHCs), changes in their length impelled by voltage ...
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Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.
PLoS Genetics, 2023 Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito +7 more
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Approaches of auditory hair cells induction from stem cells
Otorhinolaryngology and Facial Plastic Surgery, 2017 Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat +2 more
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