Results 11 to 20 of about 122,731 (252)
PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells [PDF]
The Journal of Physiology, 2017 Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip ...
M. Beurg, R. Fettiplace
semanticscholar +3 more sources
Control of Exocytosis by Synaptotagmins and Otoferlin in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2010 In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca2+ spikes. At the onset of hearing, IHC exocytosis is then exclusively driven by graded potentials, and is characterized by higher Ca2+
M. Beurg +7 more
semanticscholar +4 more sources
Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells
PLoS Biology, 2011 Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium
V. Zampini +13 more
semanticscholar +6 more sources
Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
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The developmental genetics of auditory hair cells [PDF]
Human Molecular Genetics, 2004 Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun to ...
R David, Hawkins, Michael, Lovett
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Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Cochlear hair cell loss is a leading cause of deafness in humans and other mammals. In the immature cochlea, lost hair cells are regenerated by neighboring glia-like supporting cells.
Xiao-Jun Li, Angelika Doetzlhofer
semanticscholar +1 more source
Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
doaj +1 more source
Mechanisms of Active Hair Bundle Motion in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2002 Sound stimuli vibrate the hair bundles on auditory hair cells, but the resulting motion attributable to the mechanical stimulus may be modified by forces intrinsic to the bundle, which drive it actively. One category of active hair bundle motion has properties similar to fast adaptation of the mechanotransducer channels and is explicable if gating of ...
A J, Ricci, A C, Crawford, R, Fettiplace
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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Notch Signaling and the Emergence of Auditory Hair Cells [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2000 Recent insights into the mechanisms that determine a hair cell's fate have emerged from studies on invertebrate sensory organs and the avian inner ear. These mechanisms have important implications for our understanding of the possible therapeutic management of sensorineural deafness.
J, Weir, M N, Rivolta, M C, Holley
openaire +2 more sources