A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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Progressive auditory neuropathy in patients with Leber's hereditary optic neuropathy [PDF]
, 2004 Objective: To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON).Methods: Auditory assessment was undertaken in two patients with LHON.
Ceranic, B, Luxon, LM
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Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.
PLoS Genetics, 2023 Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito +7 more
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Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells [PDF]
, 2014 Mechanotransduction in the auditory and vestibular systems depends on mechanosensitive ion channels in the stereociliary bundles that project from the apical surface of the sensory hair cells.
Corns, Laura F +3 more
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Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
, 2019 Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
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Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors [PDF]
, 2001 The deafness caused by early onset hypothyroidism indicates that thyroid hormone is essential for the development of hearing. We investigated the underlying roles of the TRa1 and TRß thyroid hormone receptors in the auditory system using receptor ...
Forrest, Douglas +8 more
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Frontiers in Cellular Neuroscience, 2015 Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine T DINH +5 more
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