Results 11 to 20 of about 91,097 (243)
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Cochlear hair cell loss is a leading cause of deafness in humans and other mammals. In the immature cochlea, lost hair cells are regenerated by neighboring glia-like supporting cells.
Xiao-Jun Li, Angelika Doetzlhofer
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Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
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Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases
Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionarily conserved and highly specialized organelles that protrude from cell membranes. Mutations in genes encoding ciliary proteins can cause structural and functional ciliary defects and consequently multiple diseases ...
Difei Wang, Jun Zhou
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A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.
PLoS Genetics, 2023 Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito +7 more
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Journal of Neurophysiology, 2021 The synapse between inner hair cells and auditory nerve fiber dendrites shows large excitatory postsynaptic currents (EPSCs), which are either monophasic or multiphasic.
E. Young +3 more
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Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Noise-induced hearing loss is a highly prevalent form of sensorineural hearing impairment affecting individuals of all ages. Noise exposure triggers a rapid increase in reactive oxygen species (ROS) levels, causing oxidative damage to ...
Jean Defourny +5 more
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