Results 31 to 40 of about 4,824,676 (233)

Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea. [PDF]

Cell Biol Int
ABSTRACT Hearing loss affects over 1.5 billion people worldwide and has substantial social, educational, and economic consequences. Although genetic studies have identified numerous hearing‐loss‐associated genes, the molecular changes accompanying noise‐induced hearing loss (NIHL) remain incompletely understood.
Batissoco AC, Alencar-Coutinho D, Ferreira-Scatone AC, Diogo-Cavassana S, Oiticica J, Lezirovitz K, Bento RF.   +6 more
europepmc   +2 more sources

Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss

Cell Death and Disease, 2022
The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels, Jun Wang, Anwen Bullen, Patricia M. White, Amy E. Kiernan   +4 more
doaj   +1 more source

Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ

Cell Reports
Summary: Hearing starts, at the cellular level, with mechanoelectrical transduction by sensory hair cells. Sound information is then transmitted via afferent synaptic connections with auditory neurons.
Mitsuo P. Sato, Nesrine Benkafadar, Stefan Heller   +2 more
doaj   +1 more source

Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Frontiers in Cell and Developmental Biology, 2022
Background: In several non-mammalian species, auditory receptors undergo cell renewal after damage. This has raised hope of finding new options to treat human sensorineural deafness.
Hao Li, Karin Staxäng, Monika Hodik, Karl-Gunnar Melkersson, Mathias Rask-Andersen, Helge Rask-Andersen   +5 more
doaj   +1 more source

Release and elementary mechanisms of nitric oxide in hair cells

, 2010
The enzyme nitric oxide (NO) synthase, that produces the signaling molecule NO, has been identified in several cell types in the inner ear. However, it is unclear whether a measurable quantity of NO is released in the inner ear to confer specific ...
Song, Haitao, Smith, Peter J S, Yamoah, Ebenezer N, Lv, Ping, Eastwood, Emily, Yevgeniy, Petrov Y, Mu, Karen, Levic, Snezana, Wei, Dongguang, Zhu, Jun, Kim, Hyo Jeong, Choong-Ryoul, Sihn, Rodriguez-Contreras, Adrian   +12 more
core   +1 more source

Insights into the regulation of hearing regeneration

Frontiers in Audiology and Otology
Our perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
doaj   +1 more source

Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice

Neural Plasticity, 2018
The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions.
Aoshuang Chang, Peng Chen, Shasha Guo, Nana Xu, Wenlu Pan, Hongzheng Zhang, Cuixian Li, Jie Tang   +7 more
doaj   +1 more source

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration

Journal of Otolaryngology - Head and Neck Surgery, 2013
Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science experimental laboratory.
Amandeep S Grewal, Julian M Nedzelski, Joseph M Chen, Vincent YW Lin   +3 more
doaj   +1 more source