Results 51 to 60 of about 55,462 (279)
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]
PLoS ONE, 2014 To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke +7 more
doaj +1 more source
Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]
, 2015 This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
core +3 more sources
Cellular studies of auditory hair cell regeneration in birds [PDF]
Proceedings of the National Academy of Sciences, 2000 A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals.
J S, Stone, E W, Rubel
openaire +2 more sources
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Insights into the regulation of hearing regeneration
Frontiers in Audiology and OtologyOur perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
doaj +1 more source
Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice
Neural Plasticity, 2018 The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions.
Aoshuang Chang +7 more
doaj +1 more source
Mammalian cochlea as a physics guided evolution-optimized hearing sensor [PDF]
, 2014 Nonlinear physics plays an essential role in hearing, from sound signal generation to sound sensing to the processing of complex sound environments. We demonstrate that the evolution of the biological hearing sensors demonstrates a dramatic reduction in ...
Gomez, Florian +2 more
core +2 more sources
Advanced Science, EarlyView.Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka +3 more
wiley +1 more source
Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration
Journal of Otolaryngology - Head and Neck Surgery, 2013 Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science experimental laboratory.
Amandeep S Grewal +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2020 Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson +5 more
doaj +1 more source