Results 41 to 50 of about 55,462 (279)

Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]

, 2017
In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A., He, X.J., Kindt, K.S., Marcotti, W., Nicolson, T., Olt, J., Petralia, R.S., Schreck, M., Sheets, L., Trapani, J.G., Wang, Y-X., Zhang, Q.   +11 more
core   +1 more source

Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]

PLoS ONE, 2013
Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe, Huifang Sun, Kevin Wang, James D Asuncion, Qi Wang, Chien-Wei Chen, Peter S Steyger, Michael E Smith, Jonathan I Matsui   +8 more
doaj   +1 more source

Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]

, 2013
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G., Avallone, B., Di Bonito, M., Franze, A. M., Mancuso, M., Narita, Y., Puelles, L., Rijli, F. M., Sequino, L., Studer, M.   +9 more
core   +5 more sources

Static length changes of cochlear outer hair cells can tune low-frequency hearing.

PLoS Computational Biology, 2018
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović, Rebecca L Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias Reichenbach   +5 more
doaj   +1 more source

Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss

Cell Death and Disease, 2022
The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels, Jun Wang, Anwen Bullen, Patricia M. White, Amy E. Kiernan   +4 more
doaj   +1 more source

Hair cell regeneration in the avian auditory epithelium

The International Journal of Developmental Biology, 2007
Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other non-mammalian species either continually produce new hair cells or regenerate them in response to trauma.
Jennifer S, Stone, Douglas A, Cotanche
openaire   +3 more sources

Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Frontiers in Cell and Developmental Biology, 2022
Background: In several non-mammalian species, auditory receptors undergo cell renewal after damage. This has raised hope of finding new options to treat human sensorineural deafness.
Hao Li, Karin Staxäng, Monika Hodik, Karl-Gunnar Melkersson, Mathias Rask-Andersen, Helge Rask-Andersen   +5 more
doaj   +1 more source

Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ

Cell Reports
Summary: Hearing starts, at the cellular level, with mechanoelectrical transduction by sensory hair cells. Sound information is then transmitted via afferent synaptic connections with auditory neurons.
Mitsuo P. Sato, Nesrine Benkafadar, Stefan Heller   +2 more
doaj   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells [PDF]

The Journal of Physiology, 2017
AbstractThroughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells.
Maryline Beurg, Robert Fettiplace
openaire   +2 more sources