Results 21 to 30 of about 23,282 (228)
Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
doaj +1 more source
eLife, 2019 The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the
Meenakshi Prajapati-DiNubila +4 more
doaj +1 more source
Control of Exocytosis by Synaptotagmins and Otoferlin in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2010 In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca2+spikes. At the onset of hearing, IHC exocytosis is then exclusively driven by graded potentials, and is characterized by higher Ca2+efficiency and improved synchronization of vesicular release. The molecular players involved in this
Beurg, Maryline +7 more
openaire +4 more sources
An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
Scientific Reports, 2021 Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux +8 more
doaj +1 more source
F1000Research, 2017 The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view.
M Charles Liberman
doaj +1 more source
Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]
PLoS ONE, 2013 In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2022 IntroductionThe inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell,
Derek J. Sauer +2 more
doaj +1 more source
Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio). [PDF]
PLoS ONE, 2013 Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval ...
Phillip M Uribe +8 more
doaj +1 more source
mTORC2 regulates auditory hair cell structure and function
iScience, 2023 mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice. HC-RicKO mice exhibited early-onset, progressive, and profound hearing loss.
Maurizio Cortada +3 more
openaire +4 more sources
Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
doaj +1 more source