Results 11 to 20 of about 23,282 (228)
Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
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The developmental genetics of auditory hair cells [PDF]
Human Molecular Genetics, 2004 Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun to ...
R David, Hawkins, Michael, Lovett
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Mechanisms of Active Hair Bundle Motion in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2002 Sound stimuli vibrate the hair bundles on auditory hair cells, but the resulting motion attributable to the mechanical stimulus may be modified by forces intrinsic to the bundle, which drive it actively. One category of active hair bundle motion has properties similar to fast adaptation of the mechanotransducer channels and is explicable if gating of ...
A J, Ricci, A C, Crawford, R, Fettiplace
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The Transduction Channel Filter in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2005 In the first step in auditory transduction, sound-induced vibrations of the stereociliary bundles on the sensory hair cells are converted into electrical signals by opening of mechanotransducer channels. Faithful transduction and hence auditory performance will be limited by the kinetic properties of these channels.
Anthony J, Ricci +3 more
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Notch Signaling and the Emergence of Auditory Hair Cells [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2000 Recent insights into the mechanisms that determine a hair cell's fate have emerged from studies on invertebrate sensory organs and the avian inner ear. These mechanisms have important implications for our understanding of the possible therapeutic management of sensorineural deafness.
J, Weir, M N, Rivolta, M C, Holley
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Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.
PLoS Genetics, 2023 Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito +7 more
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Approaches of auditory hair cells induction from stem cells
Otorhinolaryngology and Facial Plastic Surgery, 2017 Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat +2 more
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Active hair bundle movements in auditory hair cells [PDF]
The Journal of Physiology, 2006 The frequency selectivity of mammalian hearing depends on not only the passive mechanics of the basilar membrane but also an active amplification of the mechanical stimulus by the cochlear hair cells. The common view is that amplification stems from the somatic motility of the outer hair cells (OHCs), changes in their length impelled by voltage ...
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Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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The auditory of hair‐cells of the ear and their relations to the auditory nerve [PDF]
Journal of Morphology, 1893 n ...
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