Results 11 to 20 of about 4,824,676 (233)

Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction. [PDF]

Adv Sci (Weinh)
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Feng P, Zhu Q, Wang Y, Rong H, Zhang X, Wang F, Yu T, Wang W, Li J, Tian L, Liao M, Chai R, Hu Y.   +12 more
europepmc   +2 more sources

The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae [PDF]

, 1989
Auditory papillae from three species of bird (pigeon, starling, and chick), and two species of European lizard (Podarcis murolis and Podarcis sic&) were examined by scanning electron microscopy.
Pickles, J. O., Gleich, O., Brix, J., Gleich, Otto, Comis, S. D., Osborne, M. P., Köppl, C., Manley, G. A.   +7 more
core   +1 more source

Molecular biology of hearing [PDF]

, 2012
The inner ear is our most sensitive sensory organ and can be subdivided into three functional units: organ of Corti, stria vascularis and spiral ganglion.
Diensthuber, M, Stöver, T, Diensthuber, Marc, Stöver, Timo   +3 more
core   +1 more source

Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]

, 2015
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger, Axon, Patrick, Moffatt, D, Moffatt, David, Jagger, DJ, Tysome, James, Monksfield, Peter, Taylor, Ruth R., Jagger, Daniel J., Peter Monksfield, Donnelly, N, Lloyd, SK, Coulson, Chris, Irving, R, Coulson, C, Freeman, SR, Saeed, Shakeel R., Richard Irving, Simon K. Lloyd, Lloyd, Simon K., Forge, Andrew, Neil Donnelly, Freeman, Simon R., Shakeel R. Saeed, Taylor, RR, David Moffatt, Forge, A, Irving, Richard, Saeed, SR, Axon, P, Ruth R. Taylor, Monksfield, P, Simon R. Freeman, Donnelly, Neil, Chris Coulson, Tysome, J, Andrew Forge, Patrick Axon, James Tysome   +38 more
core   +1 more source

Approaches of auditory hair cells induction from stem cells

Otorhinolaryngology and Facial Plastic Surgery, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat, Navid Ahmady Roozbahany, Somayeh Niknazar   +2 more
doaj   +1 more source

Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.

PLoS Genetics, 2023
Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito, Jérôme Bourien, Monica Tizzano, Anne-Gabrielle Harrus, Jean-Luc Puel, Bice Avallone, Regis Nouvian, Michèle Studer   +7 more
doaj   +1 more source

Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]

, 2013
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Kindt, Katie, Nicolson, T., Kindt, K., Katie Kindt, Teresa Nicolson, Schmid, Bettina, Bettina Schmid, Grisham, R., Finger-Baier, Karin, Clemens Grisham, Rachel, Rachel Clemens Grisham, Nicolson, Teresa, Schmid, B., Karin Finger-Baier, Finger-Baier, K.   +14 more
core   +2 more sources

Molecular Regulation of Auditory Hair Cell Death and Approaches to Protect Sensory Receptor Cells and/or Stimulate Repair Following Acoustic Trauma

Frontiers in Cellular Neuroscience, 2015
Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine T DINH, Stefania eGONCALVES, Esperanza eBAS, Thomas R VAN DE WATER, Azel eZINE, Azel eZINE   +5 more
doaj   +1 more source

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

PLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer   +7 more
doaj   +1 more source

Energy integration describes sound-intensity coding in an insect auditory system [PDF]

, 2002
We investigate the transduction of sound stimuli into neural responses and focus on locust auditory receptor cells. As in other mechanosensory model systems, these neurons integrate acoustic inputs over a fairly broad frequency range.
Andreas V. M. Herz, Gollisch, Tim, Schütze, Hartmut, Benda, Jan, Jan Benda, Herz, Andreas V. M., Hartmut Schütze, Tim Gollisch   +7 more
core   +1 more source