Results 21 to 30 of about 89,289 (243)
Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.
PLoS Genetics, 2023 Autosomal recessive mutation of HOXB1 and Hoxb1 causes sensorineural hearing loss in patients and mice, respectively, characterized by the presence of higher auditory thresholds; however, the origin of the defects along the auditory pathway is still ...
Maria Di Bonito +7 more
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The Transduction Channel Filter in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2005 In the first step in auditory transduction, sound-induced vibrations of the stereociliary bundles on the sensory hair cells are converted into electrical signals by opening of mechanotransducer channels. Faithful transduction and hence auditory performance will be limited by the kinetic properties of these channels.
Anthony J. Ricci +3 more
openaire +3 more sources
Journal of Neurophysiology, 2021 The synapse between inner hair cells and auditory nerve fiber dendrites shows large excitatory postsynaptic currents (EPSCs), which are either monophasic or multiphasic.
E. Young +3 more
semanticscholar +1 more source
Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
doaj +1 more source
Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Noise-induced hearing loss is a highly prevalent form of sensorineural hearing impairment affecting individuals of all ages. Noise exposure triggers a rapid increase in reactive oxygen species (ROS) levels, causing oxidative damage to ...
Jean Defourny +5 more
semanticscholar +1 more source
CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
Nature Communications, 2017 Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact ...
A. Giese +12 more
semanticscholar +1 more source
Autophagy protects auditory hair cells against neomycin-induced damage
Autophagy, 2017 Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress.
Zuhong He +16 more
semanticscholar +1 more source
eLife, 2017 Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of
A. C. Vélez-Ortega +4 more
semanticscholar +1 more source
mTORC2 regulates auditory hair cell structure and function
iScience, 2023 mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice. HC-RicKO mice exhibited early-onset, progressive, and profound hearing loss.
Maurizio Cortada +3 more
openaire +5 more sources
Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
doaj +1 more source