Results 21 to 30 of about 22,677 (167)
The Transduction Channel Filter in Auditory Hair Cells [PDF]
The Journal of Neuroscience, 2005 In the first step in auditory transduction, sound-induced vibrations of the stereociliary bundles on the sensory hair cells are converted into electrical signals by opening of mechanotransducer channels. Faithful transduction and hence auditory performance will be limited by the kinetic properties of these channels.
Anthony J, Ricci +3 more
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Frontiers in Cellular Neuroscience, 2015 Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic
Christine T DINH +5 more
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Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage [PDF]
Frontiers in Cell and Developmental Biology, 2020 Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate apoptosis in HCs.
Zhenhua Zhong +18 more
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Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
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eLife, 2019 The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the
Meenakshi Prajapati-DiNubila +4 more
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F1000Research, 2017 The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view.
M Charles Liberman
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An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
Scientific Reports, 2021 Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion.
Jerome Nevoux +8 more
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Theoretical Conditions for High-Frequency Hair Bundle Oscillations in Auditory Hair Cells [PDF]
Biophysical Journal, 2008 Substantial evidence exists for spontaneous oscillations of hair cell stereociliary bundles in the lower vertebrate inner ear. Since the oscillations are larger than expected from Brownian motion, they must result from an active process in the stereociliary bundle suggested to underlie amplification of the sensory input as well as spontaneous ...
Nam, Jong-Hoon, Fettiplace, Robert
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Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]
PLoS ONE, 2013 In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati +3 more
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