SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells [PDF]
, 2009 Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane potentials, SK2 channels are ...
Adelman, John P. +8 more
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Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]
, 2017 Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
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Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
, 2018 It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones.
Bodmer, Daniel +2 more
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Zinc-finger protein A20 protects hair cells from damage made by high-power microwave
Journal of Bio-X Research, 2019 . Inner ear hair cells are important for maintaining hearing. Irreversible damage to hair cells is an important cause of sensorineural deafness. Electromagnetic radiation, especially high-power microwave, is an important threat to human health in modern ...
Feng Tang +5 more
doaj +1 more source
Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells [PDF]
, 2019 Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid.
Bozovic, Dolores, Faber, Justin
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Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
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PLoS Biology, 2023 Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs).
Christopher J Buswinka +4 more
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Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea
Journal of Otology, 2020 Objective: To investigate the role of the periotic mesenchyme (POM) in the development of sensory cells of developing auditory epithelium. Methods: Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic ...
Jingjiang Huang +7 more
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A ratchet mechanism for amplification in low-frequency mammalian hearing
, 2010 The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells. In most vertebrates the active process stems from the active motility of hair bundles.
A. J. Hudspeth +26 more
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Energy integration describes sound-intensity coding in an insect auditory system [PDF]
, 2002 We investigate the transduction of sound stimuli into neural responses and focus on locust auditory receptor cells. As in other mechanosensory model systems, these neurons integrate acoustic inputs over a fairly broad frequency range.
Benda, Jan +3 more
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