Results 51 to 60 of about 119,470 (327)

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]

, 2006
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core   +1 more source

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

EMBO Molecular Medicine, 2014
Protocadherin‐15 (Pcdh15) is a component of the tip‐links, the extracellular filaments that gate hair cell mechano‐electrical transduction channels in the inner ear.

semanticscholar   +1 more source

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]

, 2009
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen, Fuchs, Paul A., Katz, Eleonora   +2 more
core   +1 more source

Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Frontiers in Cell and Developmental Biology, 2022
Background: In several non-mammalian species, auditory receptors undergo cell renewal after damage. This has raised hope of finding new options to treat human sensorineural deafness.
Hao Li, Karin Staxäng, Monika Hodik, Karl-Gunnar Melkersson, Mathias Rask-Andersen, Helge Rask-Andersen   +5 more
doaj   +1 more source

Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells

Journal of Neuroscience, 2014
Synaptic vesicle recycling sustains high rates of neurotransmission at the ribbon-type active zones (AZs) of mouse auditory inner hair cells (IHCs), but its modes and molecular regulation are poorly understood.
Jakob Neef, Sangyong Jung, A. Wong, K. Reuter, T. Pangršič, Rituparna Chakrabarti, S. Kügler, Christine Lenz, R. Nouvian, R. Boumil, W. Frankel, C. Wichmann, T. Moser   +12 more
semanticscholar   +1 more source

GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells

Development, 2020
Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in the inner ear remain largely unknown.
Maggie S. Matern, B. Milon, Erika L. Lipford, Mark McMurray, Yoko Ogawa, Andrew Tkaczuk, Yang Song, Ran Elkon, R. Hertzano   +8 more
semanticscholar   +1 more source

Regeneration of the auditory nerve - a cell transplantation study [PDF]

, 2011
Since in mammals, the hair cells or the spiral ganglion neurons (SGNs) in the inner ear do not regenerate, damage to these cells is an irreversible process.
Palmgren, Björn
core   +1 more source

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source

Auditory Hair Cell-Specific Deletion of p27Kip1 in Postnatal Mice Promotes Cell-Autonomous Generation of New Hair Cells and Normal Hearing

Journal of Neuroscience, 2014
Hearing in mammals relies upon the transduction of sound by hair cells (HCs) in the organ of Corti within the cochlea of the inner ear. Sensorineural hearing loss is a widespread and permanent disability due largely to a lack of HC regeneration in ...
Bradley J Walters, Zhiyong Liu, M. Crabtree, Emily Coak, B. C. Cox, J. Zuo   +5 more
semanticscholar   +1 more source

PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells [PDF]

The Journal of Physiology, 2017
AbstractThroughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells.
Maryline Beurg, Robert Fettiplace
openaire   +3 more sources