Results 51 to 60 of about 22,677 (167)

A deep learning approach to quantify auditory hair cells

Hearing Research, 2021
StarDist 2D deep learning model and training dataset.
Maurizio Cortada, Loïc Sauteur, Michael Lanz, Soledad Levano, Daniel Bodmer   +4 more
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TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea

Cellular & Molecular Biology Letters, 2023
Background Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and homeostasis. Transmembrane protein
Yazhi Xing, Kun Peng, Qian Yi, Dongzhen Yu, Haibo Shi, Guang Yang, Shankai Yin   +6 more
doaj   +1 more source

Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium within a hair bundle is composed of uniformly polarized and tightly packed actin filaments. Several
V. Zampini, L. Rüttiger, S. L. Johnson, C. Franz, D. N. Furness, J. Waldhaus, H. Xiong, C. M. Hackney, M. C. Holley, N. Offenhauser, P.P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
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Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience
Clinical features of the fragile X syndrome (FXS) phenotype include intellectual disability, repetitive behaviors, social communication deficits, and, commonly, auditory hypersensitivity to acoustic stimuli.
M. Chojnacka, A. Skupien-Jaroszek, M. Dziembowska   +2 more
doaj   +1 more source

Zinc-finger protein A20 protects hair cells from damage made by high-power microwave

Journal of Bio-X Research, 2019
. Inner ear hair cells are important for maintaining hearing. Irreversible damage to hair cells is an important cause of sensorineural deafness. Electromagnetic radiation, especially high-power microwave, is an important threat to human health in modern ...
Feng Tang, Xiaoling Chen, Lifeng Jia, Hai Li, Jingya Li, Wei Yuan   +5 more
doaj   +1 more source

Autophagy protects auditory hair cells against neomycin-induced damage [PDF]

Autophagy, 2017
Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that plays important roles in the maintenance of cellular function and viability under stress. However, the role of autophagy in aminoglycoside-induced HC injury is unknown.
He, Zuhong, Guo, Lingna, Shu, Yilai, Fang, Qiaojun, Zhou, Han, Liu, Yongze, Liu, Dingding, Lu, Ling, Zhang, Xiaoli, Ding, Xiaoqiong, Liu, Dong, Tang, Mingliang, Kong, Weijia, Sha, Suhua, Li, Huawei, Gao, Xia, Chai, Renjie   +16 more
openaire   +2 more sources

Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea

Journal of Otology, 2020
Objective: To investigate the role of the periotic mesenchyme (POM) in the development of sensory cells of developing auditory epithelium. Methods: Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic ...
Jingjiang Huang, Na Zuo, Cheng Wu, Peipei Chen, Jun Ma, Chuanxi Wang, Wenyan Li, Shaofeng Liu   +7 more
doaj   +1 more source

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +1 more source

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.

PLoS Biology, 2023
Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs).
Christopher J Buswinka, Richard T Osgood, Rubina G Simikyan, David B Rosenberg, Artur A Indzhykulian   +4 more
doaj   +1 more source

Active Hair Bundle Motion Linked to Fast Transducer Adaptation in Auditory Hair Cells [PDF]

The Journal of Neuroscience, 2000
During transduction in auditory hair cells, hair bundle deflection opens mechanotransducer channels that subsequently reclose or adapt to maintained stimuli, a major component of the adaptation occurring on a submillisecond time scale. Using a photodiode imaging technique, we measured hair bundle motion in voltage-clamped turtle hair cells to search ...
A J, Ricci, A C, Crawford, R, Fettiplace
openaire   +2 more sources