Results 61 to 70 of about 22,677 (167)
Stem-cell therapy for hearing loss: are we there yet?
Brazilian Journal of Otorhinolaryngology, 2019 Introduction: Mammalian hair cells and auditory neurons do not show regenerative capacity. Hence, damage to these cell types is permanent and leads to hearing loss. However, there is no treatment that re-establishes auditory function.
Luiz Gustavo Dufner-Almeida +5 more
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Frontiers in Cellular Neuroscience, 2018 During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus +5 more
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Proliferative generation of mammalian auditory hair cells in culture
Mechanisms of Development, 2002 Hair cell (HC) and supporting cell (SC) productions are completed during early embryonic development of the mammalian cochlea. This study shows that acutely dissociated cells from the newborn rat organ of Corti, developed into so-called otospheres consisting of 98% nestin (+) cells when plated on a non-adherent substratum in the presence of either ...
Malgrange, Brigitte +9 more
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eLife, 2015 Two forms of an unconventional myosin motor protein have separate functions in the growth and maintenance of hair bundles in auditory hair cells.
Teresa Nicolson
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Regeneration and Mammalian Auditory Hair Cells [PDF]
Science, 1995 S, Chardin, R, Romand
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A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation
Cells, 2019 Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular ...
Kun Hou +8 more
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Neural Plasticity, 2017 The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology ...
Changquan Wang +5 more
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Scientific Reports, 2018 Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear.
Yukako Asai +11 more
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The force-sensing GPCR LPHN2 is indispensable for normal auditory function
Cell ReportsSummary: The conversion of force sensation into electrical signals via mechano-electrical transduction (MET) is considered the key step in auditory perception. Here, we find that the G-protein-coupled receptor (GPCR) LPHN2/ADGRL2 is expressed at the tips
Shu-Hua Zhou +18 more
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Approaches of auditory hair cells induction from stem cells
The Journal of Otorhinolaryngology and Facial Plastic SurgeryHair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear. Damage to hair cells decreases hearing sensitivity. When these delicate hair cells in the cochlea are
Khoshsirat, Shahrokh +2 more
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