Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes. [PDF]
, 2015 Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice.
Choe, Seong-Kyu +11 more
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Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
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The coupling between Ca2+ channels and the exocytotic Ca2+ sensor at hair cell ribbon synapses varies tonotopically along the mature cochlea. [PDF]
, 2017 The cochlea processes auditory signals over a wide range of frequencies and intensities. However, the transfer characteristics at hair cell ribbon synapses are still poorly understood at different frequency locations along the cochlea.
Cho, S. +4 more
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Hair cell regeneration in the avian auditory epithelium
The International Journal of Developmental Biology, 2007 Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other non-mammalian species either continually produce new hair cells or regenerate them in response to trauma.
Douglas A. Cotanche, Jennifer S. Stone
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Theoretical Conditions for High-Frequency Hair Bundle Oscillations in Auditory Hair Cells [PDF]
Biophysical Journal, 2008 Substantial evidence exists for spontaneous oscillations of hair cell stereociliary bundles in the lower vertebrate inner ear. Since the oscillations are larger than expected from Brownian motion, they must result from an active process in the stereociliary bundle suggested to underlie amplification of the sensory input as well as spontaneous ...
Jong-Hoon Nam, Robert Fettiplace
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An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells [PDF]
, 2014 International audienceA detrimental perceptive consequence of damaged auditory sen-sory hair cells consists in a pronounced masking effect exerted by low-frequency sounds, thought to occur when auditory threshold elevation substantially exceeds 40 dB ...
Avan, Paul +14 more
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Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice
Neural Plasticity, 2018 The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions.
Aoshuang Chang +7 more
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Insights into the regulation of hearing regeneration
Frontiers in Audiology and OtologyOur perception of sound is mediated by sound-sensitive hair cells in the inner ear, located in a specialized neuro-epithelium that transmits information to the auditory cortex via the auditory pathway.
Lama Khalaily, Karen B. Avraham
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Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.
PLoS ONE, 2012 During embryonic development, hair cells and support cells in the sensory epithelia of the inner ear derive from progenitors that express Sox2, a member of the SoxB1 family of transcription factors.
Stephen D Freeman, Nicolas Daudet
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TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
Cellular & Molecular Biology Letters, 2023 Background Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and homeostasis. Transmembrane protein
Yazhi Xing +6 more
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