Results 61 to 70 of about 91,097 (243)

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +1 more source

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.

PLoS Biology, 2023
Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs).
Christopher J Buswinka, Richard T Osgood, Rubina G Simikyan, David B Rosenberg, Artur A Indzhykulian   +4 more
doaj   +1 more source

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Nature Communications, 2018
In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open ...
Laura F. Corns, Stuart L. Johnson, Terri Roberts, K. M. Ranatunga, Aenea C. Hendry, F. Ceriani, S. Safieddine, K. Steel, A. Forge, C. Petit, D. Furness, C. Kros, W. Marcotti   +12 more
semanticscholar   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea

Journal of Otology, 2020
Objective: To investigate the role of the periotic mesenchyme (POM) in the development of sensory cells of developing auditory epithelium. Methods: Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic ...
Jingjiang Huang, Na Zuo, Cheng Wu, Peipei Chen, Jun Ma, Chuanxi Wang, Wenyan Li, Shaofeng Liu   +7 more
doaj   +1 more source

Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium
V. Zampini, L. Rüttiger, Stuart L. Johnson, Christoph Franz, D. Furness, Jörg Waldhaus, Hao Xiong, C. Hackney, M. Holley, Nina Offenhauser, P. P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
semanticscholar   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Stem-cell therapy for hearing loss: are we there yet?

Brazilian Journal of Otorhinolaryngology, 2019
Introduction: Mammalian hair cells and auditory neurons do not show regenerative capacity. Hence, damage to these cell types is permanent and leads to hearing loss. However, there is no treatment that re-establishes auditory function.
Luiz Gustavo Dufner-Almeida, Dayane Bernardino da Cruz, Regina Célia Mingroni Netto, Ana Carla Batissoco, Jeanne Oiticica, Rodrigo Salazar-Silva   +5 more
doaj   +1 more source

Identification of a Novel Likely Pathogenic Variant of DIAPH3 Associated With New Phenotype of Sensorineural Hearing Loss. [PDF]

Mol Genet Genomic Med
In this Chinese family with hereditary deafness, we identified a novel DIAPH3 point variant (NM_001042517.2:c.1472A>G). This variant manifests as late‐onset progressive sensorineural hearing loss, with congruent pure‐tone audiometry (PTA) and auditory brainstem response (ABR) thresholds.
Zeng L, Zheng Q, Wu X, Chen G, Xie L, Qiu W, Ning F, Bai L, Zhang Q.   +8 more
europepmc   +2 more sources

Cholesterol Influences Voltage-Gated Calcium Channels and BK-Type Potassium Channels in Auditory Hair Cells

PLoS ONE, 2011
The influence of membrane cholesterol content on a variety of ion channel conductances in numerous cell models has been shown, but studies exploring its role in auditory hair cell physiology are scarce.
E. Purcell, Liqian Liu, P. V. Thomas, R. Duncan, Stuart E Dryer   +4 more
semanticscholar   +1 more source