Results 141 to 150 of about 5,630,806 (253)

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation. [PDF]

EMBO J, 2023
Li KN, Chovatiya G, Ko DY, Sureshbabu S, Tumbar T.   +4 more
europepmc   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging. [PDF]

Front Aging, 2023
Zhang C, Wang D, Dowell R, Yi R.
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Characterisation of apoptotic responses in human keratinocytes expressnig alpha-6 integrin and CD44 [PDF]

, 2010
PhDa6 integrin has previously been proposed as a human keratinocyte stem cell markers. CD44-positive cells in epithelial tumours have been identified as potential cancer stem cells (CSCs) and display increased survival following chemotherapy ...
Wray, Helen
core   +1 more source

Cytologic Characteristics of the Feline Ovary at Different Sexual Stages

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Cytology is a valuable diagnostic tool in veterinary medicine, allowing rapid and minimally invasive diagnosis. However, its application in the reproductive tracts of small animals is limited, primarily used to assess mammary masses and stage the estrous cycle.
Alba Martí, Josep Pastor, David Prandi, Adrià Aguilar‐Catalan, Maria Montserrat Rivera del Alamo   +4 more
wiley   +1 more source

Hmmr+ Fibroblasts Facilitate Hair Regeneration by Biomechanical Sensing of Extracellular Matrix Viscoelasticity

Research
How fibroblast heterogeneity orchestrates tissue regeneration by remodeling tissue mechanical properties that guide stem cell function is not well understood.
Yuchun Tang, Mengyue Wang, Yuanli Ye, Jingwei Jiang, Wenting Huang, Yiping Zhao, Qiaoli Xie, Jinran Lin, Xiao Xiang, Dan Ke, Chunming Xu, Mingxing Lei   +11 more
doaj   +1 more source

A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling. [PDF]

iScience, 2023
Hariton WVJ, Schulze K, Rahimi S, Shojaeian T, Feldmeyer L, Schwob R, Overmiller AM, Sayar BS, Borradori L, Mahoney MG, Galichet A, Müller EJ.   +11 more
europepmc   +1 more source

Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management

Advanced Oncology, Volume 1, Issue 1, December 2026.
Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi, Nukhet Aykin‐Burns, Jingyi Chen, Younghye Song   +3 more
wiley   +1 more source