Hapten design - Open Access .click

Chinese Journal of Analytical Chemistry, 2010
Abstract The key step to develop an immunoassay for small molecular compounds is to synthesize artificial antigens with good immunogenicity. In this paper, the design and modification of hapten (e.g. the choice of modified sites, preparation of hapten derivative, choice of linking spacer), selection of carrier, coupling of hapten derivative to ...
Juan SONG +4 more
exaly +2 more sources

Hapten Design and Development of Polarization Fluoroimmunoassay for Nonylphenol

International Journal of Environmental Analytical Chemistry, 2003
Polyclonal antibodies to nonylphenol (NP), raised against two different haptenic derivatives were characterized by a rapid, homogeneous polarization fluoroimmunoassay (PFIA). The first hapten, ω-(4-hydroxyphenyl)nonanoic acid (NP9), was designed to mimic the linear NP isomer and contains hydroxyphenyl and linear alkyl chain moieties of the NP molecule.
Sergei Eremin, Milan Franek
exaly +2 more sources

Design and Synthesis of a Hapten for the Radioimmunoassay of Bupropion

Journal of Pharmaceutical Sciences, 1986
The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also
N B, Mehta, D L, Musso
openaire +2 more sources

3. good health
haptens
immunoassay

animals
mice
enzyme-linked immunosorbent assay

hapten
antibodies, monoclonal
antibodies