Results 111 to 120 of about 3,362,872 (199)

The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a

, 2012
The pleiotropic HBx protein of hepatitis B virus is linked functionally to the development of hepatocellular carcinoma (HCC) via effectors and signalling pathways of the host.
Ganeshan Mathan, Vijay Kumar, Grace Fatima   +2 more
core   +1 more source

Hepatitis virus B protein x (HBx) promotes hepatocellular carcinoma through hypoxia inducible factor (HIF)/lysyl oxidase like 2 (LOXL2) pathway

, 2015
Hepatocellular Carcinoma (HCC) being the third most lethal cancer in the world in 2008 is proposed to be highly associated with hepatitis B virus (HBV) infection. The distribution of high incident rate region of HCC and HBV were found to be very similar.
利俊裕, Lee, Chun-yu
core   +1 more source

Hepatitis B virus x protein coding sequence variation in chronically infected patient

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: Chronic infection with Hepatitis B virus (HBV) is one of the main causes of cirrhosis and hepatocellular carcinoma (HCC). The pathogenicity of the virus is determined by the multi-functional protein x (HBx).
A Mohebbi, A Shakeri-Moghaddam, Y Doudazndegan, N Lorestani, A Mir-Arab, AV Moradi, A Tabarraei   +6 more
doaj  

HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma

Cell & Bioscience
Background Hepatitis B virus (HBV) infection can exacerbate liver disease progression through multiple mechanisms, eventually leading to hepatocellular carcinoma (HCC).
Yaqun Li, Furan Wang, Zikai Geng, Tianye He, Yun Song, Jian Wu, Bin Wang   +6 more
doaj   +1 more source

The role of hepatitis B virus X protein in regulation of hypoxia inducible factor-1α and the underlying mechanisms in hepatocellular carcinoma

Zhongguo aizheng zazhi, 2015
Background and purpose: Hepatitis B virus X protein (HBx) and hypoxia inducible factor-1α (HIF-1α) play key roles in hepatocarcinogenesis and the development of hepatocellular carcinoma.
刘利平, 杨盛力, 何婉
doaj  

Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner

Virology Journal
Background Chronic hepatitis B virus (HBV) infection remains a serious public health challenge, and primary treatment strategies are unable to cure HBV infection due to the persistence of HBV covalently closed circular DNA (cccDNA) in the nuclei of cells.
Linshan Jiang, Lanlang Peng, Hong Chen, Fangli Liao, Liping Yang, Yuanyuan Ye, Gaoli Zhang, Hua Sun, Qin Hu, Weixian Chen   +9 more
doaj   +1 more source

The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53

, 2015
The hepatitis B virus (HBV) protein HBx has been implicated to induce liver cancer in transgenic mice and transactivates a variety of viral and cellular promoters.
Kobarg, J, Rui, E, de Moura, PR, Goncalves, KD   +3 more
core   +1 more source

p53-indipendent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro.

, 1998
The hepatitis B virus protein HBx is a promiscuous transactivator implicated in both cell growth and death and in the development of hepatocellular carcinoma.
BUENDIA M. A., LECOEUR H, TRIPODI, Marco, POLLICINO T, TERRADILLOS O, GOURGEON M. L, TIOLLAIS P.   +6 more
core   +1 more source

Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11. [PDF]

Emerg Microbes Infect, 2020
Shen C, Feng X, Mao T, Yang D, Zou J, Zao X, Deng Q, Chen X, Lu F.   +8 more
europepmc   +1 more source

The hepatitis B virus transactivator protein, HBx, interacts with single-stranded DNA (ssDNA). Biochemical characterizations of the HBx-ssDNA interactions.

The Journal of biological chemistry, 1996
Human hepatitis B virus X protein, HBx, is widely acknowledged as a transcriptional transactivator. While HBx has been shown to increase gene expression in trans, it is generally believed that it does not bind double-stranded DNA. Using several experimental approaches, we show that HBx interacts with single-stranded DNA in a manner that is not sequence-
I, Qadri, M E, Ferrari, A, Siddiqui
openaire   +1 more source