Results 91 to 100 of about 3,362,872 (199)

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

Journal of General Virology, 2010
The non-structural X protein, HBx, of hepatitis B virus (HBV) is assumed to play an important role in HBV replication. Woodchuck hepatitis virus X protein is indispensable for virus replication, but the duck hepatitis B virus X protein is not. In this study, we investigated whether the HBx protein is indispensable for HBV replication in vivo using ...
Masataka, Tsuge, Nobuhiko, Hiraga, Rie, Akiyama, Sachi, Tanaka, Miyuki, Matsushita, Fukiko, Mitsui, Hiromi, Abe, Shosuke, Kitamura, Tsuyoshi, Hatakeyama, Takashi, Kimura, Daiki, Miki, Nami, Mori, Michio, Imamura, Shoichi, Takahashi, C Nelson, Hayes, Kazuaki, Chayama   +15 more
openaire   +2 more sources

HBx gene accelerates cell proliferation and enhances inflammatory factors expression through ERK1/2 signaling pathway

Di-san junyi daxue xuebao, 2020
Objective To investigate the effects of HBx gene on hepatocyte cycle and immune system in vivo based on self-developed mouse model with stable expression of HBx gene.
HUANG Xin, ZHANG Siyao, WANG Xue, DU Bin, WU Nan, ZHOU Mengyao, FENG Tao   +6 more
doaj   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues

, 2015
Chronic infection of the hepatitis B virus (HBV) is one of the causes leading to liver cancer. The 3.2 kb genome of HBV encodes four proteins: core antigen, surface antigen, a DNA polymerase and the X protein (HBx).
Kobarg, J, Rui, E, de Moura, PR, Goncalves, KD   +3 more
core   +1 more source

Hemoglobin Lepore‐Boston‐Washington: A Rare Cause of Unmeasurable HbA1c and Diagnostic Challenge in Diabetes

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Filippo Russo, Silvia Trombetti, Maria Rosaria Storino, Raffaele Sessa, Carmela De Felice, Giuseppe Schiavone, Michela Grosso   +6 more
wiley   +1 more source

Indeterminate Phase/Grey Zone of Chronic Hepatitis B: Clinical Features, Outcomes and Molecular Insights

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a global public health challenge, with a high risk of complications such as cirrhosis, hepatocellular carcinoma (HCC) and death. As outlined in current international society guidelines, antiviral therapies are aimed at preventing progression of liver disease to life‐threatening complications ...
Maria Stella Franzè, Teresa Pollicino, Jean‐Michel Pawlotsky, Vincent Leroy, Giovanni Raimondo, Giuliana Amaddeo   +5 more
wiley   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

Cell Reports, 2016
The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function.
Christopher M. Murphy, Yanping Xu, Feng Li, Kouki Nio, Natalia Reszka-Blanco, Xiaodong Li, Yaxu Wu, Yanbao Yu, Yue Xiong, Lishan Su   +9 more
doaj   +1 more source

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

, 2011
Hepatitis B virus (HBV) encodes the regulatory HBx protein, which is required for virus replication, although its specific role(s) in the replication cycle remains under investigation.
Manish Kumar, Sung Yun Jung, Betty L. Slagle, Jun Qin, Charles R. Madden, Amanda J. Hodgson   +5 more
core   +1 more source

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates

Exploration of Targeted Anti-tumor Therapy
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancers with high mortality rate. Among its various etiological factors, one of the major risk factors for HCC is a chronic infection of hepatitis B virus (HBV).
Agustiningsih Agustiningsih, Muhammad Rezki Rasyak, Turyadi, Sri Jayanti, Caecilia Sukowati   +4 more
doaj   +1 more source