Results 101 to 110 of about 3,362,872 (199)

The mechanism of HBx protein to promote the initiation and progression of hepatocellular carcinoma

Infection International, 2018
AbstractHepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the third most common cause of death from cancer, after lung and stomach cancer. Hepatitis B virus (HBV) infection is closely related to HCC and is a major cause of HCC. HBV is a lysogenic virus of the hepadnavirus family.
Muyao Zhang, Xing Wei, Zhenfei Wang
openaire   +1 more source

Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro

, 2015
Infection with the hepatitis B virus has been identified as one of the major causes of liver cancer. A large body of experimental work points to a central role for the virally encoded protein HBx in this form of carcinogensis.
Goncalves, KA, Kobarg, J, Rui, E, Rooney, RJ, Moura, PR   +4 more
core   +1 more source

HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line

, 2009
The relationships between epithelial-to-mesenchymal transition (EMT), hepatitis B virus X protein (HBx), and the non-receptor tyrosine kinase c-Src were investigated. The HBx gene transfected SMMC-7721 cells underwent morphological changes from a classic
Li, Hao Lin, Li, Xiao Wu, Dong, Jia Hong, Xiong, Yan, Yang, Shi Zhong, Zhang, Yi, Zhang, Yu Jun, Zhang, Lei Da   +7 more
core   +1 more source

HBx targets centrosomal protein TAX1BP2 to promote genomic instability

, 2015
Centrosome is a major microtubule-organizing centre for regulating spindle assembly and bipolarity.Evidence suggests that cancer is a multi-step accumulation process of genomic instability resulted from centrosome dysfunction.
Tang, HC, Li, SK, Lau, PY, Zhou, Y, Ching, YP   +4 more
core  

Inhibition of DKK2 in hepatocellular carcinoma cell lines by hepatitis B virus X protein [PDF]

Jichu yixue yu linchuang, 2020
Objective To analyze the effect of hepatitis B virus X protein on the expression of DKK2 in different hepatoma cell lines and its possible mechanism.
WANG Xiao-yan, DU Hong, WANG Wei, QUAN Hui-qin
doaj  

HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species

, 2008
Hepatitis B virus X protein (HBx) is involved in viral metabolism and progression of liver disease. Iron metabolism plays a significant role in liver disease.
Gu, Jin-Mo, Lim, Seung Oe, Oh, Sae Jin, Jung, Guhung, Sung, Je Kyeong, Yoon, So-Mi, Seong, Je Kyung   +6 more
core   +1 more source

Differential Expression of HBx Protein in the Liver from Patients with Chronic hepatitis, Cirrhosis and Hepatocellular Carcinoma

, 1997
Background/aims : Hepatocellular carcinoma is frequently associated with hepatitis B virus infection and HBx protein is suspected to be the main cause of hepatitis B virus related hepatocellular carcinoma.
Cho, HS, Lee, JH, Jin, YM
core   +1 more source

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication. [PDF]

J Virol, 2023
Ariffianto A, Deng L, Abe T, Matsui C, Ito M, Ryo A, Aly HH, Watashi K, Suzuki T, Mizokami M, Matsuura Y, Shoji I.   +11 more
europepmc   +1 more source

rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK-eIF2α-ATF4 axis in an HBx protein-dependent manner. [PDF]

Cell Mol Biol Lett, 2023
Choi YM, Kim DH, Jang J, Choe WH, Kim BJ.   +4 more
europepmc   +1 more source

The HBx protein from hepatitis B virus coordinates a redox-active Fe-S cluster. [PDF]

J Biol Chem, 2022
Ueda C, Langton M, Chen J, Pandelia ME.
europepmc   +1 more source