Results 81 to 90 of about 3,362,872 (199)
, 2008 Recent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely
Tang, Kai-Fu +12 more
core +1 more source
Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation
Cell Reports, 2019 Summary: To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence complementation screening to identify potential physical interactions ...
Guangyun Tan +13 more
doaj +1 more source
Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells
Analytical Cellular Pathology, 2021 Liver cancer is a major contributor to cancer-related death with poor survival for sufferers. Meanwhile, Hepatic B virus X protein (HBx) and XB130 are likely to participate in the pathogenesis of liver cancer. However, the detailed mechanism of HBx/XB130
Chaoqun Huang +4 more
doaj +1 more source
SOCS3 is required for HBx-induced IRS1 protein expression.
, 2013 (A) The degradation of IRS1 by cooperation between HBx and SOCS3. Top; Mock and HBx-constitutively expressing HepG2 cells were transiently transfected with Myc-tagged SOCS3.
JaeHun Cheong (366273) +2 more
core +1 more source
BMC Cancer, 2012 Background To understand the molecular mechanisms of caveolin-1 downregulation by hepatitis B virus X protein (HBx). Methods The DNA methylation status of the caveolin-1 promoter was examined by nested methylation-specific PCR of 33 hepatitis B virus ...
Yan Jun +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 39, 13 July 2026.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
HBx upregulates USP37 mRNA and protein levels.
, 2014 (A) Cell lysates from Huh7 cells transfected with Vector control or HA-X0 construct were run on SDS-PAGE gel and were blotted for USP37 and normalized against GAPDH (B) Total RNA was isolated and USP37 mRNA levels were measured by RT-qPCR using specific ...
Vijay Kumar (377076) +1 more
core +1 more source
Journal of Medical Virology, Volume 98, Issue 7, July 2026.ABSTRACT Chronic hepatitis B virus (HBV) infection remains a significant global health burden. Although the canonical HBV proteins are well‐studied, the pathological roles of HBV spliced variants and their encoded proteins are poorly understood. In this study, we investigate the cancer‐promoting potential of hepatitis B doubly spliced protein (HBDSP ...
Xiazhen Xu +8 more
wiley +1 more source
Viruses, 2013 The role of hepatitis B virus (HBV) X protein (HBx) in the regulation of HBV replication remains controversial. In the present study, the role of HBx in regulating HBV replication was initially investigated in both HepG2 and Huh7 in vitro cell lines with
Xing Cheng +5 more
doaj +1 more source
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source