Results 71 to 80 of about 3,362,872 (199)

Hepatitis B virus X gene inhibits hepatocyte apoptosis in mice via Akt/mTOR pathway

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of hepatitis B virus X (HBx) on apoptosis and cell cycle of hepatocytes in mice with normal immune functions and explore the underlying mechanisms.
WANG Xue, HUO Bennian, LIU Jie, HUANG Xin, ZHANG Siyao, FENG Tao   +5 more
doaj   +1 more source

From Undifferentiated Connective Tissue Disease to Common Variable Immunodeficiency: A Novel NFKB1 Mutation in a Pediatric Case

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Common variable immunodeficiency (CVID) may initially manifest as undifferentiated connective tissue disease (UCTD) in the absence of recurrent infections or hypogammaglobulinemia. In patients presenting with warning signs, neither older age nor normal immunoglobulin levels should preclude consideration of CVID; early genetic testing is ...
Yu‐Jie Hu, Sheng Hao, Dan Feng, Bing‐Xue Huang, Wen‐Yan Huang   +4 more
wiley   +1 more source

HBx increases SOCS3 expression.

, 2013
(A) The protein and mRNA expression of SOCS3 in wild-type and HBx-transgenic mice in a stage-specific manner. The liver tissues of control mice and HBx homozygous transgenic mice were immunoblotted with anti-SOCS3 antibody.
JaeHun Cheong (366273), KyeongJin Kim (366271), Kook Hwan Kim (366272)   +2 more
core   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

HBx Sensitizes Cells to Oxidative Stress-induced Apoptosis by Accelerating the Loss of Mcl-1 Protein via Caspase-3 Cascade

Molecular Cancer, 2011
Background Oxidative stress has been implicated in the pathogenesis of a wide spectrum of human diseases, including Hepatitis B virus (HBV)-related liver disease.
Tu QianQian, Chang YanXin, Sun HanYong, Li Liang, Yang GuangZhen, Chen Lei, Hu Liang, Wu MengChao, Wang HongYang   +8 more
doaj   +1 more source

Differential functions of C- and N-terminal hepatitis B x protein in liver cells treated with doxorubicin in normoxic or hypoxic condition. [PDF]

PLoS ONE, 2012
Hepatitis viral B x protein (HBx), a hepatocarcinogen, is frequently mutated. Hypoxia influences the growth of HCC and also the sensitivity of tumor cells to treatments.
Davor Kin-Fan Chau, George Gong Chen, Haitao Zhang, Billy Cheuk Sing Leung, Sukying Chun, Paul Bo-San Lai   +5 more
doaj   +1 more source

The Malaysian Society of Gastroenterology and Hepatology Consensus Statements on Prevention and Early Detection of Hepatocellular Carcinoma in Malaysia

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2639-2655, September 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer‐related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence‐based, locally relevant recommendations for the prevention and early detection of HCC.
Su Yin Lau, Victoria Sinq‐Ling Kok, Soek‐Siam Tan, Syuhada Dan Adnan, Wei‐Lin Ng, Ban‐Hong Ang, Nur Yazmin Yaacob, Yeong Yeh Lee, Senamjit Kaur, Rosmawati Mohamed, Ping‐Foo Wong, Lee‐Ling Lim, Mohana Letchumanan, Shireene Ratna Vethakkan, Nurain Mohd Noor, Siow‐Foon Tan, Tiong‐Lim Low, Lee‐Boon Kiew, Wah‐Kheong Chan   +18 more
wiley   +1 more source

HBx decreases IRS1 expression.

, 2013
(A) The effects of HBx protein on IRS1 expression in wild-type and HBx-transgenic mice. Proteins in liver extracts from control and HBx-transgenic mice were immunoblotted with anti-IRS1, anti-phospho-IRS1 (Ser307), anti-IRβ, anti-HBx, and anti-Actin ...
JaeHun Cheong (366273), KyeongJin Kim (366271), Kook Hwan Kim (366272)   +2 more
core   +1 more source

Dietary Terpenoids in Advancing Biofilm‐Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano‐Facilitated Functional Delivery

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder, Aditi Dey, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Sudhriti Maity, Navin Kumar, Soumya Pandit, Vaseem Raja, Shubham Sharma, Shashi Prakash Dwivedi, Mithul Rajeev, Juwita Ratna Dewi, Lola Sanayeva, Dilbar Azimova   +14 more
wiley   +1 more source

Over expression, purification and characterization of hepatitis B virus X protein (HBx) and its interacting partner HBx - interacting protein (XIP). [PDF]

, 2002
by Cheung Yuk Yin.Thesis (M.Phil.)--Chinese University of Hong Kong, 2002.Includes bibliographical references (leaves xx-xxviii).Abstracts in English and Chinese.Acknowledgements --- p.iAbstract --- p.ii摘要 --- p.iiiTable of Content --- p ...

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