Results 61 to 70 of about 3,362,872 (199)
Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux +6 more
wiley +1 more source
HBx protein induces gp96 expression.
, 2013 (A) Real-time PCR and western blot analysis of gp96 mRNA and protein levels in Huh7 cells transfected with the HBV expression vector pHBV or a GFP expression vector pEGFP-C1 (mock) or the empty vector pcDNA3.1 as a control.
Fusheng Wang (102710) +7 more
core +1 more source
Advanced Science, Volume 13, Issue 50, 7 September 2026.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Di-san junyi daxue xuebao, 2021 Objective To investigate the dynamic changes and the roles of COX-2 and its downstream factors in the carcinogenic process using a mouse model stably expressing hepatitis B virus X (HBx). Methods The expression of HBx in HBx-EGFP-14-19 cells was detected
WU Nan +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Laboratory Animal Research, 2020 The hepatitis B virus (HBV) infects approximately 240 million people worldwide, causing chronic liver disease (CLD) and liver cancer. Although numerous studies have been performed to date, unfortunately there is no conclusive drug or treatment for HBV ...
Dae-Yeul Yu
doaj +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang +5 more
wiley +1 more source
HBx, especially HBx-d382, enhances CyclinD1 expression.
, 2012 (A) CyclinD1 protein level of the engineered LO2 cells. (B) The histogram of CyclinD1 mRNA and protein level in LO2/HBx and LO2/HBx-d382 cells, compared with LO2/pcDNA3.0 cells ...
Zhouhua Hou (142578) +6 more
core +1 more source
Deubiquitylation of hepatitis B virus X protein (HBx) by ubiquitin-specific peptidase 15 (USP15) increases HBx stability and its transactivation activity [PDF]
Scientific Reports, 2017 AbstractHepatitis B virus X protein (HBx) plays important roles in viral replication and the development of hepatocellular carcinoma. HBx is a rapid turnover protein and ubiquitin-proteasome pathway has been suggested to influence HBx stability as treatment with proteasome inhibitors increases the levels of HBx protein and causes accumulation of the ...
Zhi-Jun Su +6 more
openaire +2 more sources
Infection and Drug Resistance, 2022 Bin Li,1 Yonggang Li,2 Shuhua Li,1 Hongwei Li,1 Ling Liu,1 Yao Xu3 1Laboratory of Immunology and Pathogenic Biology, Experimental Teaching Center of Basic Medicine, Jinzhou Medical University, Jinzhou City, Liaoning Province, 121001, People’s Republic of
Li B, Li Y, Li S, Li H, Liu L, Xu Y
doaj