Results 51 to 60 of about 3,362,872 (199)
Viruses, 2023 Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), one of the most prevalent malignant tumors worldwide that poses a significant threat to human health.
Ning Han +5 more
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The Hepatitis B Virus X Protein (Hbx) Induces A Migratory Phenotype in A Cd44–Dependent Manner: Possible Role of Hbx in Invasion and Metastasis [PDF]
Hepatology, 2001 The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the development of hepatocellular carcinoma (HCC). However, its possible contribution to the metastatic spreading of liver tumors has not been explored so far.
E, Lara-Pezzi +8 more
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Frontiers in Microbiology, 2023 Hepatitis B, a global health concern caused by the hepatitis B virus (HBV), infects nearly 2 billion individuals worldwide, as reported by the World Health Organization (WHO).
Fei Wang +7 more
doaj +1 more source
HBx-Derived Constrained Peptides Inhibit the Secretion of Hepatitis B Virus Antigens
, 2018 Hepatitis B virus (HBV) infection is the primary cause of cirrhosis and liver cancer. Protein–protein interactions (PPIs) between HBV x protein (HBx) and its host targets, including Bcl-2, are important for cell death and viral replication. No modulators
Xiaodong Shi +11 more
core +1 more source
HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling [PDF]
Journal of Biological Chemistry, 1998 The X-gene product (HBx) of the hepatitis B virus plays essential roles in viral replication and the generation of hepatocellular carcinoma. Although the mechanism for HBx action is unclear, HBx may exert its pleiotropic functions through the stimulation of signal transduction pathways including the Ras/mitogen-activated protein kinase cascade and/or ...
Y H, Lee, Y, Yun
openaire +2 more sources
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.Here we demonstrate that weak HB CH donor cyanostilbenes promote water/ion transport through their ability to form less‐ordered transient water channels within the lipid bilayer with increased water permeability and NO3−/ Cl− selectivity. ABSTRACT Transmembrane water transport strongly depends on how dynamic, translocating water clusters are stabilized
Ioan Stroia +6 more
wiley +2 more sources
, 2017 Maspin suppresses tumor progression by promoting cell adhesion and apoptosis and by inhibiting cell motility. However, its role in tumorigenesis of hepatocellular carcinoma (HCC) remains unclear.
Chen, Wen-Shu;Yen, Chia-Jui;Chen, Yun-Ju;Chen, Jhen-Yu;Wang, Li-Yun;Chiu, Shu-Jun;Shih, Wen-Ling;Ho, Chien-Yi;Wei, Tzu-Tang;Pan, Hsiao-Lin;Chien, Pei-Hsuan;Hung, Mien-Chie;Chen, Ching-Chow;Huang, Wei-Chien +1 more
core +1 more source
Microorganisms, 2022 Chronic hepatitis B virus infection is the dominant cause of hepatocellular carcinoma, the main cause of cancer death. HBx protein, a multifunctional protein, is essential for pathogenesis development; however, the underlying mechanisms are not fully ...
Khoren K. Epremyan +5 more
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Technical standards for hepatitis B virus X protein (HBx) research [PDF]
Hepatology, 2015 Chronic infection with hepatitis B virus (HBV) is a risk factor for developing hepatocellular carcinoma (HCC). The life cycle of HBV is complex and has been difficult to study because HBV does not infect cultured cells. The HBV regulatory X protein (HBx) controls the level of HBV replication and possesses an HCC cofactor role.
Betty L, Slagle +5 more
openaire +2 more sources
Biochemistry and Biophysics Reports, 2022 Background: Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for 10%–20% of the total HCC numbers. Its clinical features include the occurrence in the younger generation, large tumors, and poor prognosis.
Chiyumi Oda +13 more
doaj +1 more source