Results 131 to 140 of about 400,342 (335)

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source

HBV + HCV = HCC?

Gut, 1999
See article on page 284 Most people infected with hepatitis C virus (HCV) develop a chronic infection with persistent viraemia and are at risk of progressive liver damage. However, the outcome of chronic HCV infection is extremely variable and is influenced by many factors, including HCV genotype, HCV viral load, route of infection, age at infection,
openaire   +3 more sources

Interfacial Roughness‐Reinforced Magnetic Nanosheet Colloidal Gels for Stable Embolization and Magnetothermal Therapy of Hepatic Tumor

Advanced Science, EarlyView.
A rough‐interface reinforcement strategy is implemented to construct nanosheet‐mica‐based magnetic colloidal hydrogels with enhanced mechanical robustness and injectability. These hydrogels achieve stable vascular embolization and effective magnetothermal performance, offering synergistic therapeutic benefits in hepatic tumor treatment.
Xingyu Liu, Sheng Chen, Yonghong Song, Bing Chen, Xu Yan, Rui Qiu, Jinlong Hu, Baoqiang Cao, Hanye Xing, Tao Zhou, Liang Dong, Yang Lu   +11 more
wiley   +1 more source

PLAUR+ Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu, Yanzhao Zhou, Gaoxiang Li, Bingwen Zhu, Fang Wu, Jinxue Zhou, Xiaobing Chen, Bo Qin, Yanxia Gao, Fazhan Wang, Yong Jiang, Wenxin Xu   +11 more
wiley   +1 more source

Relationship between primary liver hepatocellular carcinoma volumes on portal-venous phase CT imaging [PDF]

, 2016
The liver is an important organ in the body. It is located under the rib cage on the right side. The liver performs many important functions, it processes food for nutrients that the body requires and also helps in the detoxification of harmful materials.
Aisaborhale, Ehimen Edward
core   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Targeted FABP5 co‐delivery nanoparticles amplify RFA‐induced ferroptosis and intratumoral immune rewiring via STING/TBK1 pathway activation in HCC. The pH‐responsive lipid nanoshell was integrated with cyclic RGD peptide (cRGD) and red blood cell membrane (RBCM), and encapsulated with superparamagnetic iron oxide (SPIO) and sgFABP5 to construct FS@RBCM/
Bufu Tang, Xiaojie Zhang, Yiting Sun, Jinhua Luo, Qiaoyou Weng, Cong Zhang, Zilin Wang, Shiji Fang, Yangrui Xiao, Liyun Zheng, Jianfei Tu, Rongfang Qiu, Yang Yang, Zhongwei Zhao, Weiqian Chen, Minjiang Chen, Jiansong Ji   +16 more
wiley   +1 more source

Isolation and Identification of Hepatitis Contagiosa Canis Virus (Hcc Virus) from an Enzootic Outbreak in a Dog Kennel

, 1972
Finn Saxegaard
openalex   +2 more sources

The correlation between histologic features and the echogenicity in Asian hepatocellular carcinomas (HCCs) is not applicable to non-Asian HCCs. [PDF]

, 2000
Saichiro Tanaka
openalex   +1 more source