Results 131 to 140 of about 289,858 (341)
High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. [PDF]
, 2019 IntroductionPrognosis after resection of hepatocellular carcinoma (HCC) is highly variable. Compared to clinicopathologic factors, the use of molecular markers to predict outcome has not been well studied.
Antonia, Ricardo J +10 more
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Advanced Science, EarlyView.This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng +16 more
wiley +1 more source
Advanced Science, EarlyView.PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou +10 more
wiley +1 more source
The Molecular Basis of Amino Acids Sensing
Advanced Science, EarlyView.Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang +3 more
wiley +1 more source
Long Noncoding RNA (lncRNA) MT1JP Suppresses Hepatocellular Carcinoma (HCC) in vitro
Cancer Management and Research, 2020 Wenhui Mo,* Ying Dai,* Jianqing Chen, Liwei Liang, Shuqi Xu, Xuanfu Xu Department of Gastroenterology, Shidong Hospital of Shanghai, Shanghai 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuanfu ...
Mo W, Dai Y, Chen J, Liang L, Xu S, Xu X
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Advanced Science, EarlyView.Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao +13 more
wiley +1 more source
Journal of Hepatocellular Carcinoma, 2021 Shuqi Mao,1 Xi Yu,1 Yuying Shan,1 Rui Fan,2 Shengdong Wu,1 Caide Lu1 1Department of Hepatopancreatobiliary Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 2Medical Quality ...
Mao S, Yu X, Shan Y, Fan R, Wu S, Lu C
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New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis [PDF]
, 1999 Jiawen Tian +6 more
openalex +1 more source
Evolving epidemiology of HCC in Spain
JHEP ReportsThe epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023.
Margarita Sala +69 more
openaire +4 more sources
The Evolution, Expansion and Evaluation of the Family Economic Security Program [PDF]
, 2016 In 2008, the Fund for Women & Girls of Fairfield County's Community Foundation created the Family Economic Security Program (FESP). The goal of the program is to assist low- and moderate-income working students – particularly women who are single parents
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