Results 131 to 140 of about 160,497 (241)

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

A Machine Learning Model to Improve Risk Adjustment Accuracy in Medicare. [PDF]

Health Serv Res
Shenfeld DK, Warrenburg L, Silvert E, Guido M, Makar M, Joynt Maddox K, Navathe AS, Parikh RB, Emanuel EJ.   +8 more
europepmc   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Disparities in Diagnosis, Management, and Outcomes of Hepatocellular Carcinoma: A Review of Global and Sociodemographic Factors. [PDF]

J Gastrointest Cancer
Zheng C, Araque M, Quiej A, Buchanan-Peart KA, Jones PD.   +4 more
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Spectroscopic Insights Into the Role of the Coverage of *CO and *H on Bifurcation of Ethylene and Ethanol Pathways in Carbon Dioxide Electroreduction

Carbon Energy, EarlyView.
Zhao et al. control the coverage of *CO or *H intermediates by introducing foreign metal into Cu nanoparticles. The increased *CO coverage on Ag‐doped and Zn‐doped Cu promotes the generation of multi‐carbon products while the increased *H coverage of Co‐doped and Pd‐doped Cu enhances the selectivity of oxygenates. ABSTRACT As key reaction intermediates
Zi‐Hao Zhao, Wenchao Liu, Zhan Liu, Dan Ren   +3 more
wiley   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

ScRNA-Seq Deciphers an Autocrine EFNA1-EPHA1 Loop That Reprograms the Microenvironment in Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Chen Y, Tang Y, Ning Y, Yang Y, Tian R, Mao Y, Feng Z, Lin W, Wang D, Feng X.   +9 more
europepmc   +1 more source

Immunosuppressive Microenvironment Reprogramming by Synergistic Sonodynamic Therapy of Phthalocyanine‐MOF Hybrids for Hepatocellular Carcinoma

Exploration, EarlyView.
Hepatocellular carcinoma presents a formidable clinical challenge, constructing a hypoxic and immunosuppressive microenvironment that renders conventional therapies largely ineffective. In response, we have developed Pc@Zr‐MOF, a phthalocyanine‐integrated metal‐organic framework hybrid engineered to penetrate this defensive barrier.
Han Wu, Lihui Gu, Jiahao Xu, Chuyue Zhang, Mingda Wang, Chao Li, Lanqing Yao, Yongkang Diao, Yuchen Li, Fujie Chen, Huixuan Fan, Yuze Zhao, Feng Shen, Tian Yang   +13 more
wiley   +1 more source